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№ КАС: 61036-62-2
Molecular formula:C77H77N9O31Cl2.R
Молекулярная масса:
Standard：JP/ EP
Content：≥900ug/mg
Packaging:1KG/Tin
Use to:Glycopeptides
Telicoplanin: An Effective Antibacterial Agent
Telicoplanin is a significant glycopeptide antibiotic used in the management of various bacterial infections.
1. Общая и фармакокинетическая информация
| Аспект | Подробнее |
| Источник | Produced by Actinoplanes teichomyceticus |
| Химический класс | гликопептид |
| Администрация | Intravenous injection (for systemic infections), can also be used intramuscularly in some cases |
| Распределение | Distributes well in most body tissues, including bone, but has limited penetration into the cerebrospinal fluid without inflammation |
| метаболизм | Undergoes minimal metabolism in the body |
| Ликвидация | Primarily excreted unchanged in the urine, with a long elimination half – life of approximately 47 – 100 hours in adults |
2. Механизм действия
| Экшн | объяснение |
| Ингибирование синтеза клеточной стенки | Telicoplanin binds to the D – alanyl – D – alanine terminal of the lipid – linked peptidoglycan precursors in the cell wall of Gram – positive bacteria. This binding prevents the transglycosylation and transpeptidation reactions that are essential for the elongation and cross – linking of the peptidoglycan chains. As a result, the cell wall synthesis is disrupted, leading to cell lysis and death of the bacteria. |
3. Клиническое применение и побочные эффекты
| категорию | Подробнее |
| Клинические применения | Used mainly for treating severe infections caused by Gram – positive bacteria. It is effective against methicillin – resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Streptococcus pyogenes, and Enterococcus faecalis. Indicated for skin and soft – tissue infections, bloodstream infections, endocarditis, and osteomyelitis. |
| Побочные эффекты | Infusion – related reactions such as rash, pruritus, and rarely anaphylaxis can occur. Nephrotoxicity is a concern, especially with high doses or in patients with pre – existing renal impairment, manifested as increased serum creatinine levels. Thrombocytopenia may also be observed in some patients. |
Telicoplanin plays a crucial role in the treatment of Gram – positive bacterial infections, but its use needs to be carefully monitored to manage potential adverse effects.
Фабрика и отгрузка
