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Код каталога 816109
CAS NO.22204-53-1
Чистота 97%
Номер MDLMFCD00010500
EINEC244-838-7
Молекулярная формула C14H14O3
Молекулярный вес 230.2592
Температура плавления: 156~158°С
| Аспект | Подробнее |
| Фармакологический механизм | DL – Naproxen is a non – steroidal anti – inflammatory drug (NSAID). It works by inhibiting the cyclooxygenase (COX) enzymes, specifically COX – 1 and COX – 2. By blocking these enzymes, it reduces the synthesis of prostaglandins. Prostaglandins are involved in the body’s inflammatory response, pain perception, and fever regulation. The inhibition of prostaglandin synthesis leads to a decrease in inflammation, pain, and fever. |
| Клинические применения | In clinical practice, DL – Naproxen is widely used for the relief of pain associated with various conditions. It is effective in treating mild to moderate pain, such as headaches, menstrual cramps, and musculoskeletal pain. It is also prescribed for the management of inflammatory conditions like rheumatoid arthritis and osteoarthritis, where it helps to reduce joint pain, swelling, and stiffness, improving the patient’s quality of life and joint function. |
| Неблагоприятные реакции | However, like other NSAIDs, DL – Naproxen may cause several adverse reactions. Gastrointestinal side effects are common, including nausea, vomiting, indigestion, and in severe cases, peptic ulcers and gastrointestinal bleeding. It can also affect the kidneys, potentially leading to renal impairment, especially in patients with pre – existing kidney problems or those on long – term use. Cardiovascular risks such as an increased risk of heart attack and stroke have also been associated with the use of NSAIDs, including DL – Naproxen, especially at higher doses. |
| Меры предосторожности | Patients with a history of peptic ulcers, heart disease, or kidney disease should use DL – Naproxen with caution. It is important to avoid alcohol while taking this drug as it can increase the risk of gastrointestinal bleeding. Pregnant and breastfeeding women should consult their healthcare providers before using DL – Naproxen, as it may have potential effects on the fetus or nursing infant. Additionally, patients should inform their doctors about all the medications they are taking to avoid possible drug interactions. |
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