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Код каталога 80021362
CAS NO.27200-12-0
Чистота 98%
Номер MDLMFCD00189451
Молекулярная формула C15H12O8
Молекулярный вес 320.25
Температура плавления: 240~256°С
| категорию | Информация |
|---|---|
| Биологическая активность | Dihydromyricetin (DHM) is a flavonoid with multiple biological benefits. It exhibits anti-inflammatory, antioxidant, anti-tumor, and anti-viral activities. It is also a potent dihydropyrimidinase inhibitor with an IC50 of 48 μM. Additionally, DHM can activate autophagy by inhibiting the mTOR signaling pathway. |
| Механизмы действия | DHM inhibits the formation of mTOR complexes (mTORC1/2), which helps in regulating cell growth and survival. It also acts as an inhibitor of the influenza virus RNA-dependent RNA polymerase, with an IC50 of 22 μM. |
| Pharmacological Applications | DHM has been studied for its effects on various systems, including cardiovascular, urinary, digestive, nervous, and respiratory systems. It is recognized for its high biosafety, making it a promising candidate for clinical applications. |
| Результаты исследований | Recent studies have shown that DHM can attenuate brain aging in rats induced by D-galactose through the miR-34a-mediated SIRT1/mTOR signal pathway. It also suppresses breast carcinogenesis by inhibiting the mTOR signaling pathway. |
| Хранение и стабильность | DHM should be stored at -20°C as a powder for up to 2 years. When dissolved in a solvent, it should be stored at -80°C for up to 1 year. |
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