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Код каталога 80021076
CAS NO.91421-42-0
Чистота 98%
Номер MDLMFCD06656294
Молекулярная формулаC20H15N3O6
Молекулярный вес 393.3496
Температура плавления: 182~186°С
| категорию | Информация |
|---|---|
| химические свойства | Rubitecan (9-Nitrocamptothecin) is a semisynthetic derivative of camptothecin. It has the molecular formula C₂₀H₁₅N₃O₆ with a molecular weight of 393.35. It is a yellow crystalline powder. |
| Физические свойства | It has a melting point of 182-186°C, a density of 1.63 g/cm³, and is insoluble in water. |
| Механизм действия | Rubitecan is an inhibitor of topoisomerase I, a nuclear enzyme that controls DNA topology. It stabilizes the topoisomerase I-DNA covalent complex, preventing DNA repair and leading to cell death. |
| Противоопухолевая активность | It has shown broad antitumor activity, particularly in pancreatic cancer and ovarian cancer. In vitro studies have demonstrated cytotoxicity against various cell lines, with IC₅₀ values ranging from 0.112 to 0.479 μM. |
| Клинические испытания | Clinical trials have explored its use in treating various cancers, including bladder cancer, esophageal cancer, gastric cancer, and pancreatic cancer. |
| Условия хранения | As a powder, it should be stored at -20°C for up to 3 years or at 4°C for up to 2 years. When dissolved in a solvent, it is stable for 2 years at -80°C and 1 year at -20°C. |
| Приложения | Rubitecan is primarily used in cancer research and as a potential therapeutic agent for refractory cancers. It is also being explored as a payload for antibody-drug conjugates (ADCs) due to its potent antitumor activity. |
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