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Код каталога 80020990
CAS NO.515-03-7
Чистота 98%
Номер MDLMFCD00869558
EINEC208-194-0
Молекулярная формула C20H36O2
Молекулярный вес 308.4986
Точка плавления: 95~100℃.
Boiling point: 218~220℃ (19 mmHg)
| категорию | Информация |
|---|---|
| химические свойства | Sclareol is a diterpene alcohol with the molecular formula C₂₀H₃₆O₂ and a molecular weight of 316.5. It is a natural compound isolated primarily from the herb Salvia sclarea (clary sage). |
| Физические свойства | It appears as a white to off-white crystalline solid. It has low water solubility but is lipophilic, making it suitable for encapsulation in liposomes and nanoparticles. |
| Природные источники | Sclareol is predominantly found in the essential oil of Salvia sclarea (clary sage), where it constitutes 11.5-15.7% of the oil. It is also present in other plants such as Cistus creticus, Nicotiana glutinosa, and Cleome spinosa. |
| Биологическая активность | –Противовоспалительное действие: Sclareol inhibits NF-κB and MAPK signaling pathways, reducing inflammation in various models.<br>-Противоопухолевая активность: It has been shown to enhance the efficacy of chemotherapeutic agents like doxorubicin and induce apoptosis in cancer cells.<br>-Противомикробные эффекты: Exhibits antibacterial and antifungal properties.<br>-Anti-diabetic and Anti-hypertensive: Potential applications in managing diabetes and hypertension. |
| Приложения | –Фармацевтика: Used in the synthesis of Ambrox (ambroxide), a fragrance compound.<br>-Cosmetics and Food: Utilized as a natural flavor and fragrance ingredient.<br>-Лекарственное использование: Investigated for its potential in treating various diseases, including cancer, inflammation, and COVID-19. |
| Системы доставки | Due to its low water solubility, sclareol is often encapsulated in liposomes, lipid nanoparticles (LNPs), and nanostructured lipid carriers (NLCs) to enhance its bioavailability and therapeutic efficacy. |
| Исследовательский потенциал | Sclareol is being explored as a potential candidate for treating COVID-19 and Parkinson’s disease, highlighting its broad-spectrum biological activities |
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