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English Synonyms 5-(4′-(Bromomethyl)-[1,1′-biphenyl]-2-yl)-1-trityl-1H-tetrazole
Код каталога 80020643
CAS NO.124750-51-2
Чистота 96%
Номер DLMFCD00665221
Molecular Formula C33H25N4Br
Молекулярный вес 557.4824
Температура плавления: 135~138°С
| категорию | Информация |
|---|---|
| химические свойства | – Molecular Formula: C₃₅H₂₇BrN₅<br>- Molecular Weight: 596.58 g/mol |
| Физические свойства | – Appearance: White to off-white crystalline solid.<br>- Melting Point: Not explicitly reported, but similar compounds typically have high melting points. |
| Синтез | – Synthesized using N-bromosuccinimide and dibenzoyl peroxide in tetrachloromethane.<br>- Involves a condensation reaction with triphenylmethyl tetrazole and 4′-bromomethylbiphenyl-2-yl moieties. |
| Приложения | – Used as a synthetic intermediate in the development of pharmaceuticals and materials.<br>- Potential applications in bioconjugation and bioorthogonal chemistry due to its reactive bromomethyl group. |
| Информация по технике безопасности | – Store in a cool, dry place, protected from moisture and light.<br>- Handle with care due to the presence of bromomethyl groups, which can be reactive. |
| Условия хранения | – Store at room temperature or refrigerate if necessary to maintain stability. |
Имена и идентификаторы
| Имя | n-(triphenylmethyl)-5-(4′-bromomethylbiphenyl-2-yl-)terazole |
| Синонимы | ББТТ ТТББ Bromobiphenyl trityltetrazole 4-Bromomethyl-2′-(2-trityl-2H-tetrazol-5-yl)biphenyl N-(Trityl)-5-(4′-Bromomethyl Biphenyl-2-Yl)-Tetrazole 5-(4′-(Bromomethyl)Biphenyl-2-yl)-1-Trityl-1H-Tetrazole 4-Bromomethyl-2′-(2-trityl-2H-tetrazol-5-yl)biphenyl (TTBB) n-(triphenylmethyl)-5-(4′-bromomethylbiphenyl-2-yl)terazole N-(triphenylmethy)-5-(4′-bromomethylbiphenyl-2-yl-)tetrazol n-(triphenylmethyl)-5-(4′-bromomethylbiphenyl-2-yl-)terazole N-(Трифенилметил)-5-(4'-бромметилбифенил-2-ил-)тетразол N-(Triphenylmethyl)-5-(4′-Bromomethyl Biphenyl-2-Yl)-Tetrazole N-(Triphenylmethyl)-5-[4′-(Bromomethylbiphenyl)-2-YL] Tetrazole N-(triphenyl methyl)-5-(4′-(bromomethyl)biphenyl 2-yl)tetrazole 5-(4′-bromomethyl-1,1′-biphenyl-2-yl)-1-triphenylmethyl-1h-tetrazole 5-(4′-bromomethyl-1,1′- biphenyl-2-yl)-1-triphenylmethyl-1H-Tetrazole 1H-Tetrazole,5-[4′-(bromomethyl)[1,1′-biphenyl]-2-yl]-1-(triphenylmethyl) 5-[4′-(bromomethyl)[1,1′-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole 5-[4′-(Bromomethyl) [1,1′-biphenyl]-2-yl]-1-(triphenylmethyl)-1H-tetrazole |
| CAS | 124750-51-2 |
| EINECS | 603-010-9 |
| InChI | InChI=1/C33H25BrN4/c34-24-25-20-22-26(23-21-25)30-18-10-11-19-31(30)32-35-36-37-38(32)33(27-12-4-1-5-13-27,28-14-6-2-7-15-28)29-16-8-3-9-17-29/h1-23H,24H2 |
124750-51-2 – Физико-химические свойства
| Молекулярная формула | C33H25BrN4 |
| Молярная масса | 557.48 |
| Плотность | 1.282g / cm3 |
| Температура плавления | 152-155 ° C |
| Болинг Точка | 718.441 ° C при 760 мм рт.ст. |
| Точка возгорания | 388.299 ° C |
| Давление пара | 0 мм рт. Ст. При 25 ° C |
| рКа | 0.29 ± 0.10 (прогнозируемый) |
| Условия хранения | Инертная атмосфера, 2-8°C |
| Стабильность | Чувствительность к влаге |
| Показатель преломления | 1.66 |
| Используйте | As a drug Irbesartan Intermediate |
124750-51-2 – Риск и безопасность
| Идентификаторы ООН | ООН 2811 6.1 / PG III |
| Класс опасности | 6.1 |
| Группа упаковки | III |
124750-51-2 – Добывающая и перерабатывающая промышленность
| Перерабатывающие продукты | Тритилолмесартан Ethyl-2-Ethoxy-1-[[(2′-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate 1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2′-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl]Methyl]-, ethyl ester |
124750-51-2 – Введение
N-(Triphenylmethyl)-5-(4 ‘-bromomethylbiphenyl-2-yl) tetrazole, also known as Br-PhABZ or TBATB. Its chemical structure is as follows:
Nature:
1. Appearance: White crystalline solid.
2. Solubility: Soluble in a variety of organic solvents, such as dimethylformamide (DMF), dichloromethane (DCM), etc.
3. melting point: about 150 ℃ to 160 ℃.
Использование:
1. Br-PhABZ is widely used in the field of organic synthesis, especially in tandem reactions (such as Suzuki coupling, Stille coupling, etc.).
2. As the ligand of the dual catalyst, Br-PhABZ can coordinate with transition metals to generate complexes with catalytic activity for asymmetric synthesis and other reactions.
3. Br-PhABZ can also be used as a raw material for high energy density materials and organic light-emitting diodes (OLED).
Метод:
The synthesis of Br-PhABZ is generally divided into two steps:
1. First, in the presence of trityl alcohol, phenylmagnesium bromide and bibenzaldehyde are reacted to obtain 4 ‘-bromomethylbiphenyl-2-formaldehyde.
2. Next, 4 ‘-bromomethylbiphenyl-2-carbaldehyde and pentaphenylmethylated tetraaminopyrimidine are reacted under basic conditions to obtain N-(triphenylmethyl)-5-(4’-bromomethylbiphenyl-2-yl) tetrazole.
Safety Information: The toxicity and danger of Br-PhABZ are limited, but it is still necessary to pay attention to safe operation when used as a chemical.
2. contact with skin, eyes or body, should immediately rinse with plenty of water, and wash hands. If you feel unwell, you should seek medical help.
3. During storage and handling, avoid contact with oxidants and strong acids to prevent dangerous reactions.
4. in the indoor environment must be properly ventilated to avoid inhalation of its vapor or dust. For prolonged operation, wear personal protective equipment such as gloves, goggles and protective clothing.
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Фабрика и отгрузка
