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CAS NO.5003-48-5
Чистота 98%
Номер MDLMFCD00864257
Молекулярная формула C17H15NO5
Молекулярный вес 313.3047
Температура плавления: 175~181°С
| категорию | Подробнее |
|---|---|
| химические свойства | Molecular formula: C16H15NO4<br>Molecular weight: 285.30 g/mol<br>Chemical name: 2-Acetoxybenzoic acid p-acetamidophenyl ester |
| Физические свойства | Внешний вид: Белый кристаллический порошок |
| Механизм действия | Benorilate is a prodrug that releases both aspirin and paracetamol (acetaminophen) upon metabolism. Aspirin inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and providing anti-inflammatory, analgesic, and antipyretic effects. Paracetamol acts centrally to reduce pain and fever. |
| Терапевтическое Использование | Показания к применению: Used for mild to moderate pain, such as headaches, toothaches, menstrual pain, and musculoskeletal pain.<br>Снижение температуры: Effective in reducing fever.<br>Воспаление: Provides anti-inflammatory effects for conditions like arthritis. |
| Дозировка | Взрослые: 0.5–1.0 g orally, 3–4 times daily.<br>Пожилой: Maximum daily dose of 2.6 g. |
| Побочные эффекты | Gastrointestinal disturbances, hypersensitivity reactions, tinnitus, heartburn, drowsiness, dizziness. |
| Противопоказания | Aspirin Sensitivity: Not suitable for individuals allergic to aspirin.<br>Кровотечения: Avoid in patients with bleeding disorders.<br>Язвенная болезнь: Contraindicated in patients with active peptic ulcers.<br>Тяжелые поражения печени или почек: Use with caution in severe liver or kidney impairment. |
| Условия хранения | Store in a cool, dry place, protect from light and moisture |
Имена и идентификаторы
| Имя | benorilate |
| Синонимы | benoral benortan benorilate Benorylate benorilato fenasparate aspirinacetaminophenester p-acetamidophenylacetylsalicylate 4-acetamidophenyl O-acetylsalicylate 4′-(acetamido)phenyl-2-acetoxybenzoate 2-acetoxy-4′-(acetamino)phenylbenzoate 4-(acetylamino)phenyl 2-(acetyloxy)benzoate |
| CAS | 5003-48-5 |
| EINECS | 225-674-5 |
| InChI | InChI=1/C17H15NO5/c1-11(19)18-13-7-9-14(10-8-13)23-17(21)15-5-3-4-6-16(15)22-12(2)20/h3-10H,1-2H3,(H,18,19) |
5003-48-5 – Физико-химические свойства
| Молекулярная формула | C17H15NO5 |
| Молярная масса | 313.3 |
| Плотность | 1.2016 (приблизительная оценка) |
| Температура плавления | 177-181 ℃ |
| Болинг Точка | 453.11 ° C (приблизительная оценка) |
| Точка возгорания | 279 ° C |
| Растворимость воды | 20 мг/л (21 ºC) |
| Растворимость | ДМСО (слегка), метанол (слегка) |
| Давление пара | 1.23E-11 мм рт. Ст. При 25 ° C |
| Внешний вид | SOLID |
| Цвет | Белый |
| Merck | 14,1045 |
| рКа | 14.17 ± 0.70 (прогнозируемый) |
| Условия хранения | Запечатанный в сухом, комнатной температуре |
| Показатель преломления | 1.4500 (оценка) |
| Физические и химические свойства | White crystalline powder. Melting Point 175-176 °c. Soluble in hot alcohol, insoluble in water. |
| Используйте | Esterification of acetaminophen and aspirin, suitable for rheumatoid arthritis, rheumatoid arthritis, Head Pain, neuralgia, fever, etc |
5003-48-5 – Риск и безопасность
| RTECS | VO0720000 |
| Токсичность | LD50 in mice, rats (mg/ml): 2000, ~10000 orally; 1255, 1830 i.p. (Robertson) |
Справочная информация
| Pharmacological action and mechanism of action | Benorilate is a neutral compound that binds aspirin and acetaminophen with ester bonds. It has antipyretic and analgesic effects, and has less adverse reactions than aspirin. Patients are easy to tolerate. After oral administration, it is not hydrolyzed in the gastrointestinal tract, absorbed in the intestine and quickly reaches an effective concentration in the blood. The characteristic is that it rarely causes gastrointestinal bleeding. |
| неблагоприятные реакции | 1. mild gastrointestinal reactions such as vomiting, constipation, heartburn, etc. have also been reported to cause diarrhea. 2. It can cause rash. 3. still visible drowsiness, dizziness, disorientation and other neurological and mental symptoms. |
| использование | this product is the esterification product of aspirin and paracetamol, and is a new anti-inflammatory, antipyretic, analgesic and rheumatic drug. Adverse reactions are smaller than aspirin, and patients are easy to tolerate. After oral administration, it is not hydrolyzed in the gastrointestinal tract, is easily absorbed and quickly reaches an effective concentration in the blood. Mainly used for rheumatoid arthritis, acute and chronic rheumatoid arthritis, rheumatic pain, cold and fever, headache, postoperative pain, neuralgia, etc. Adverse reactions include vomiting, dyspepsia and constipation. Sleepiness, dizziness and disorientation can still be seen. When the dosage is too large, most people may have tinnitus and deafness. Use with caution in patients with liver and kidney function impairment. Aspirin allergy is contraindicated. The oral LD50 was 2000mg/kg for mice and -10000mg/kg for rats. The LD50 was 1255mg/kg for mice and 1830mg/kg for rats. The esterification of acetaminophen and aspirin, suitable for rheumatoid arthritis, rheumatoid arthritis, headache, neuralgia, fever, etc. |
| Способ производства | Acetylsalicylic acid is acyl chlorinated to generate acetylsalicylchloride, which is then condensed with p-acetamido phenol to obtain benorilate. |
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