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Код каталога 80017818
CAS NO.61825-94-3
Чистота 98%
Номер MDL
MFCD00866327
EINEC Molecular FormulaC8H14N2O4Pt
Молекулярный вес 397.2858
Температура плавления: 285~300°С
| Аспект | Подробнее |
|---|---|
| Механизм действия | Oxaliplatin is an alkylating agent that binds to DNA, forming cross-links that inhibit DNA replication and transcription, leading to cell cycle arrest and apoptosis. It works synergistically with fluoropyrimidines like 5-fluorouracil. |
| Фармакокинетика | Oxaliplatin undergoes rapid non-enzymatic biotransformation and is not metabolized by the CYP450 enzyme system. It has a triphasic elimination with a significant terminal half-life. Approximately 50% is excreted in urine and 2% in feces. |
| Администрация | Administered via intravenous infusion over 2 hours. In cases of acute toxicity, the infusion may be extended to 6 hours. Pre-treatment with antiemetics is recommended to prevent chemotherapy-induced nausea and vomiting. |
| Побочные эффекты | Common side effects include peripheral sensory neuropathy, nausea, vomiting, diarrhea, abdominal pain, constipation, anemia, thrombocytopenia, leukopenia, and elevated liver enzymes. |
| Противопоказания | Contraindicated in patients with hypersensitivity to platinum compounds, grade 3 or 4 peripheral sensory neuropathy, severe renal impairment, and during pregnancy or breastfeeding. |
| мониторинг | Regular blood tests, urine tests, liver and renal function tests, and electrocardiograms are required to monitor patients. Neurological exams are also essential to assess for oxaliplatin-induced peripheral neuropathy. |
| Лекарственное взаимодействие | Oxaliplatin may interact with various drugs, including baricitinib, chloramphenicol, clozapine, QT-prolonging agents, and taxane derivatives, potentially enhancing adverse effects or diminishing therapeutic efficacy. |
| Условия хранения | Oxaliplatin should be stored at 4°C, protected from light. In solvent, it can be stored at -80°C for 6 months or -20°C for 1 month. |
| Использование не по прямому назначению | Used off-label for advanced biliary adenocarcinoma, esophageal and gastric cancers, refractory neuroendocrine tumors, non-Hodgkin lymphoma, advanced ovarian cancer, pancreatic cancer, and testicular cancer. |
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