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Код каталога 80017755
CAS NO.117976-90-6
Чистота 95%
Номер MDLMFCD02092688
olecular FormulaC18H20N3O3Sna
Молекулярный вес 381.4245
| Аспект | Подробнее |
|---|---|
| Механизм действия | Rabeprazole sodium is a proton pump inhibitor (PPI) that irreversibly binds to the H+/K+-ATPase enzyme system on the secretory surface of gastric parietal cells, inhibiting the final step of acid production. It is activated in the acidic environment of the parietal cell canaliculus and forms covalent bonds with the enzyme, leading to sustained inhibition of gastric acid secretion. |
| Показания к применению | – Treatment of gastroesophageal reflux disease (GERD), including erosive esophagitis.<br>- Prevention and treatment of gastric and duodenal ulcers.<br>- Management of Zollinger-Ellison syndrome.<br>- Used in combination with antibiotics to treat Helicobacter pylori infection. |
| Фармакокинетика | –Поглощение: Rapidly absorbed after oral administration, with peak plasma concentrations reached within 3 to 4 hours.<br>-Распределение: Volume of distribution is approximately 1.1 L/kg.<br>-метаболизм: Metabolized in the liver via CYP2C19 and CYP3A4.<br>-Ликвидация: Half-life is approximately 1 hour (shorter in fast metabolizers, longer in slow metabolizers).<br>-экскреция: Выводится в основном с мочой. |
| Побочные эффекты | –Общий: Headache, nausea, vomiting, diarrhea, constipation, abdominal pain, flatulence, dizziness.<br>-Серьезный: Acute tubulointerstitial nephritis (kidney inflammation), Clostridioides difficile infection (severe diarrhea), severe skin reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis), hypomagnesemia (low magnesium levels), vitamin B12 deficiency, increased risk of bone fractures.<br>-Аллергические реакции: Anaphylaxis, rash, swelling, difficulty breathing. |
| Меры предосторожности | – Monitor for signs of kidney problems, severe diarrhea, or skin reactions.<br>- Regular blood tests may be needed to check for vitamin B12 deficiency or hypomagnesemia.<br>- Use with caution in patients with liver disease.<br>- Avoid concomitant use with rilpivirine-containing products.<br>- Inform healthcare providers of all medications and supplements being taken. |
| Особые соображения | – Long-term use (over 1 year) may increase the risk of bone fractures, vitamin B12 deficiency, and hypomagnesemia.<br>- May worsen or cause lupus erythematosus; monitor for joint pain or skin rash.<br>- Do not stop taking rabeprazole without consulting a doctor.<br>- May affect the absorption of certain medications (e.g., iron, digoxin, ketoconazole). |
| Условия хранения | Store at room temperature, away from moisture and light |
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