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Код каталога 80017098
CAS NO.1716-12-7
Чистота 98%
Номер MDLMFCD00800247
Молекулярная формула EINEC C10H11NaO2
Молекулярный вес 186.1829
| Аспект | Подробнее |
|---|---|
| Химическая структура | Sodium 4-phenylbutyrate (4-PBA sodium) has the chemical formula C₁₀H₁₃NaO₂. It is a derivative of 4-phenylbutyric acid with a molecular weight of 188.2. |
| Механизм действия | – Acts as a histone deacetylase (HDAC) inhibitor, leading to cell cycle arrest, differentiation, and apoptosis in various tumor cells.<br>- Functions as a chemical chaperone, rescuing the trafficking of misfolded proteins.<br>- Inhibits endoplasmic reticulum (ER) stress, which is implicated in protein folding and cellular stress responses.<br>- Weakly blocks histone deacetylase activity (IC₅₀ = 0.4 mM), resulting in increased histone acetylation. |
| Клиническое использование | – Used to treat urea cycle disorders by stimulating urinary nitrogen excretion.<br>- Investigated for its potential in cancer therapy due to its antineoplastic and differentiation-inducing properties.<br>- Studied for its effects on ER stress and protein misfolding in various diseases. |
| Фармакокинетика | – Undergoes β-oxidation to phenylacetate, a prodrug for phenylacetate.<br>- Stable for 2 years from the date of purchase when stored as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| Физические свойства | – Appearance: White to slightly yellow solid.<br>- Solubility: ≥5 mg/mL in water.<br>- Melting Point: 224–226°C (decomposition). |
| Условия хранения | Store at room temperature, sealed and protected from moisture. |
| Побочные эффекты | – Common: Loss of appetite, menstrual changes (delayed/irregular/absent periods).<br>- Serious: Drowsiness, easy bruising/bleeding, fast/pounding heartbeat, mental/mood changes, signs of metabolic imbalance. |
| Исследования приложений | – Used in studies related to cancer, ER stress, and protein misfolding.<br>- Investigated for its effects on viral infections, such as ASFV, by inhibiting viral protein synthesis and disrupting viral-induced histone hypoacetylation |
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