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Код каталога 80017063
CAS NO.635-65-4
Чистота 98%
Номер MDLMFCD00005499
EINEC211-239-7
Молекулярная формула C33H36N4O6
Молекулярный вес 584.6621
| Аспект | Подробнее |
|---|---|
| Определение | Bilirubin is a yellow compound that occurs in the normal catabolic pathway that breaks down heme in red blood cells. |
| Production and Metabolism | – Produced by the breakdown of heme in reticuloendothelial cells, primarily in the spleen.<br>- Conjugated with glucuronic acid in the liver to form water-soluble bilirubin, which is excreted into bile and eventually eliminated through feces or urine. |
| Физиологические функции | – Acts as a potent antioxidant, scavenging reactive oxygen species.<br>- Has immunosuppressive effects and may function as a hormone, influencing various cellular signaling pathways.<br>- Activates the nuclear receptor PPARα, promoting fat burning and reducing adiposity and blood glucose levels. |
| Клиническое значение | – Elevated levels can indicate liver or bile duct problems, or increased red blood cell destruction.<br>- Low levels are associated with conditions like Gilbert’s syndrome, which is characterized by mild hyperbilirubinemia but generally benign.<br>- Moderate increases in bilirubin levels have been linked to reduced risks of metabolic and cardiovascular diseases. |
| Тестирование и измерение | – Blood tests measure total bilirubin, direct (conjugated) bilirubin, and indirect (unconjugated) bilirubin.<br>- Used to diagnose jaundice, liver diseases, and monitor the effectiveness of treatments. |
| Возможное терапевтическое использование | – Strategies to increase plasma bilirubin levels are being explored for combating chronic diseases like obesity and diabetes.<br>- Bilirubin nanoparticles are being investigated as potential therapeutic agents for metabolic and cardiovascular diseases |
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