TEL
+ 86-21-6420 0566
Код каталога 80017028
CAS NO.14897-39-3
Чистота 98%
Номер MDLMFCD00056847
EINEC Molecular Formula C37H46NNaO12
Молекулярный вес 719.7504
| Аспект | Подробнее |
|---|---|
| Определение | Rifampicin SV Sodium is a semisynthetic antibiotic belonging to the ansamycin class, derived from rifamycin B produced byStreptomyces mediterranei. It is used primarily for its antimicrobial properties. |
| Механизм действия | – It inhibits bacterial RNA synthesis by binding to the β subunit of bacterial DNA-dependent RNA polymerase, preventing transcription.<br>- This mechanism is bactericidal and affects both Gram-positive and Gram-negative bacteria, as well as mycobacteria. |
| Клиническое использование | – Used for treating infections caused by multidrug-resistant bacteria.<br>- Approved for treating traveler’s diarrhea caused by non-invasive strains ofКишечная палочкаand other gastrointestinal infections.<br>- Investigated for use in irritable bowel syndrome with diarrhea (IBS-D) and small intestinal bacterial overgrowth (SIBO). |
| Фармакокинетика | – Poorly absorbed orally, with a bioavailability of <0.1%.<br>- Distributed primarily in the gastrointestinal tract, with a volume of distribution of 101.8 L.<br>- Metabolized in the liver to a 25-deacetyl metabolite.<br>- Eliminated mainly through feces (90% of the dose), with a half-life of approximately 3 hours. |
| Лекарственные формы | – Available as modified-release tablets designed to release the drug in the distal small intestine and colon. |
| Условия хранения | Store at -20°C in a freezer. |
| Побочные эффекты | Generally well-tolerated, with minimal systemic side effects due to its poor absorption. |
| Противопоказания | Hypersensitivity to rifamycins. |
| Исследования приложений | – Investigated for its potential in treating various bacterial infections and its role in preventing antibiotic-associated colitis.<br>- Studied for its efficacy in IBS-D and other intestinal pathologies with infectious components. |
Отказ от ответственности: приведенный выше контент предназначен только для справки и общения среди инсайдеров отрасли и не гарантирует его точность или полноту. Согласно соответствующим законам и правилам, а также правилам этого веб-сайта, подразделения или лица, которые покупают соответствующие товары, должны получить действительные квалификации и условия квалификации.
Фабрика и отгрузка
