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Белый кристаллический порошок, гигроскопичен, растворим в воде. Используется как контрацептив (утеротоник).
Внешний вид Белый или почти белый порошок.
Растворимость Хорошо растворим в воде. Растворяется в разбавленных растворах уксусной кислоты и этанола (96%).
Время удерживания ВЭЖХ соответствует эталонному
Ph 3.0-6.0
Вода (КФ) ≤5.0%
Родственные вещества (по данным ВЭЖХ) По отдельности ≤1.5% Вместе ≤5.0%
Аминокислоты Asp 0.90~1.10Glu 0.90~1.10Pro 0.90~1.10Gly 0.90~1.10Leu 0.90~1.10Ile 0.90~1.10Tyr 0.70~1.05Half-Cys 1.40~2.10
Уксусная кислота (по данным ВЭЖХ) 6%-10%
Бактериальный эндотоксин <300 МЕ/мг
Общее количество бактерий ≤100 КОЕ/г
Анализ (по ВЭЖХ) 93.0%~102.0%
Активность Эффективность≥480 МЕ/мг
Заключение Соответствует EP 8.0 и USP 37.
Хранение В защищенном от света месте при температуре от 2 °C до 8 °C.
Упаковка: 10 г/мешок; 1 кг/мешок.
Хранение: В защищенном от света месте при температуре от 2 °C до 8 °C. Избегать попадания влаги.
| Объект | Подробнее |
| Химическое название | Окситоцин |
| Номер по CAS | 50 - 56 - 6 |
| Молекулярная формула | \(C_{43}H_{66}N_{12}O_{12}S_{2}\) |
| Молекулярная масса | 1007.2 |
| Молекулярная структура | It is a peptide hormone composed of 9 amino acids. The structure contains a ring formed by a disulfide bond between two cysteine residues, which is crucial for its biological activity. The sequence of amino acids is Cys – Tyr – Ile – Gln – Asn – Cys – Pro – Leu – Gly – NH₂. |
| Внешний вид | Обычно представляет собой белый или почти белый кристаллический порошок. |
| Растворимость | Soluble in water and acetic acid. This solubility allows it to be easily dissolved in body fluids for proper physiological functioning. |
| Физиологическая роль | In Childbirth: It plays a central role in the process of labor. Oxytocin stimulates uterine contractions, which helps in the expulsion of the fetus from the uterus. It also promotes the release of prostaglandins, further enhancing uterine contractions. Выброс молока: In lactating women, oxytocin is responsible for the milk – ejection reflex. When a baby suckles, nerve signals trigger the release of oxytocin from the posterior pituitary gland, causing the myoepithelial cells around the mammary alveoli to contract and eject milk. Social and Emotional Function: Oxytocin is also involved in social bonding, trust, and pair – bonding. It has been associated with feelings of empathy, love, and attachment in both humans and animals. |
| Медицинские применения | Индукция труда: When necessary, synthetic oxytocin (pitocin) can be administered intravenously to induce labor in cases where the pregnancy has reached full – term or when there are medical indications for early delivery. Controlling Postpartum Hemorrhage: It is used to reduce bleeding after childbirth by promoting uterine contractions, which helps to compress the blood vessels in the uterus. |
| Стабильность | Oxytocin is relatively stable under appropriate storage conditions, typically refrigerated. However, exposure to heat, light, or extreme pH can degrade the hormone and reduce its activity. |
| Вопросы безопасности | When used appropriately in medical settings, oxytocin is generally safe. But excessive or improper use can lead to strong and uncoordinated uterine contractions, which may pose risks to both the mother and the fetus. In some cases, it can cause water intoxication if large amounts are administered without proper fluid balance management. |
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