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CAS NO.1018899-04-1
| Объект | Подробнее |
| Химическое название | Селегилин |
| Номер по CAS | 14611-52-0 |
| Молекулярная формула | \(C_{13}H_{17}N\) |
| Молекулярная масса | 187.28 |
| Молекулярная структура | Selegiline has a structure consisting of a phenyl – propyl – amine backbone. It contains a phenyl ring attached to a three – carbon chain with an amino group at one end. There are also methyl groups attached to the nitrogen atom and within the propyl chain. |
| Внешний вид | Обычно представляет собой белый или почти белый кристаллический порошок. |
| Растворимость | Soluble in organic solvents like ethanol, methanol, and chloroform. It has limited solubility in water. This solubility profile impacts the formulation of pharmaceutical products, often requiring specific techniques to ensure proper drug delivery. |
| Фармакологический класс | Selective monoamine oxidase B (MAO – B) inhibitor |
| Механизм действия | Selegiline selectively inhibits MAO – B, an enzyme that breaks down dopamine in the brain. By blocking this enzyme, selegiline increases the levels of dopamine available in the synaptic cleft. This helps to enhance the function of the dopaminergic system, which is compromised in conditions such as Parkinson’s disease. Additionally, it may have some antioxidant properties and can potentially reduce the formation of free radicals that can damage neurons. |
| Медицинские применения | Болезнь Паркинсона: Used as an adjunct to levodopa – carbidopa therapy in the treatment of Parkinson’s disease. It can help to improve motor symptoms, reduce the “wearing – off” phenomenon associated with levodopa use, and potentially delay the progression of the disease in some cases. It may also be used in the early stages of Parkinson’s disease to manage symptoms before the need for full – scale levodopa treatment. |
| Стабильность | Stable under normal storage conditions, typically at room temperature in a dry and dark place. However, exposure to high humidity, extreme temperatures, or strong oxidizing or reducing agents can lead to degradation of the drug, affecting its potency. |
| Вопросы безопасности | Common side effects may include nausea, dizziness, dry mouth, and insomnia. At higher doses, it can potentially interact with tyramine – containing foods (such as cheese, red wine) and cause a hypertensive crisis due to its MAO – inhibiting properties. Selegiline may also interact with other medications, such as antidepressants, increasing the risk of serotonin syndrome. It is important to monitor blood pressure and other vital signs during treatment, especially in patients with a history of cardiovascular disease. |
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