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CAS NO.135062-02-1
Репаглинид применяется для лечения сахарного диабета II типа.
| Объект | Подробнее |
| Химическое название | Репаглинид |
| Номер по CAS | 135062-02-1 |
| Молекулярная формула | \(C_{27}H_{36}N_2O_4\) |
| Молекулярная масса | 452.59 |
| Молекулярная структура | Repaglinide has a unique structure. It consists of a bicyclic heterocyclic core, with a carboxyl group and several other aliphatic and aromatic side chains attached. The structure allows it to interact specifically with the sulfonylurea receptor on pancreatic beta – cells. |
| Внешний вид | Обычно представляет собой белый или почти белый кристаллический порошок. |
| Растворимость | Sparingly soluble in water. It has better solubility in organic solvents like ethanol and methanol. This solubility characteristic is crucial for formulating it into various pharmaceutical dosage forms such as tablets. |
| Фармакологический класс | Meglitinide class of antidiabetic drugs |
| Механизм действия | Repaglinide binds to the sulfonylurea receptor on pancreatic beta – cells. This binding leads to the closure of potassium channels, depolarization of the cell membrane, and subsequent opening of calcium channels. The influx of calcium ions stimulates the release of insulin granules from the beta – cells. In this way, it helps to lower blood glucose levels by increasing insulin secretion in a glucose – dependent manner. |
| Медицинские применения | Тип 2 Сахарный диабет: Approved for the treatment of type 2 diabetes. It is used to control blood sugar levels in patients who cannot achieve adequate glycemic control with diet and exercise alone. Repaglinide can be used as monotherapy or in combination with other antidiabetic agents such as metformin. It is particularly useful for patients who have post – meal hyperglycemia, as its short – acting nature allows for better control of blood glucose spikes after eating. |
| Стабильность | Stable under normal storage conditions, typically at room temperature in a dry place protected from light. However, exposure to high humidity, extreme temperatures, or strong oxidizing or reducing agents may cause degradation of the drug, which can affect its potency and safety. |
| Вопросы безопасности | Common side effects include hypoglycemia, which is more likely to occur when the drug is used inappropriately or in combination with other drugs that can lower blood sugar. Weight gain is also a possible side effect, similar to some other drugs that stimulate insulin secretion. Repaglinide may interact with other medications. For example, drugs that inhibit or induce the cytochrome P450 enzymes (such as some antifungal drugs and rifampin) can affect the metabolism of repaglinide, leading to altered drug levels and potentially increased risk of side effects or reduced efficacy. |
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