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English Synonyms 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile
Код каталога 100116
CAS NO.850649-61-5
Чистота 98%
Номер MDLMFCD09833196
EINEC Molecular FormulaC18H21N5O2
Molecular Weight339.4 Appearance:Powdery granules
| категорию | Контент |
|---|---|
| Родовое имя | Алоглиптин |
| Бренд: | Nesina, Kazano (alogliptin/metformin), Oseni (alogliptin/pioglitazone) |
| Класс наркотиков | Dipeptidyl Peptidase-4 (DPP-4) Inhibitor |
| Механизм действия | Alogliptin selectively inhibits DPP-4, an enzyme that degrades incretin hormones such as GLP-1 and GIP. By inhibiting DPP-4, alogliptin prolongs the activity of these hormones, leading to increased insulin secretion and decreased glucagon release, thereby regulating glucose homeostasis. |
| Показания к применению | Used for the treatment of type 2 diabetes mellitus. It can be used alone or in combination with other antidiabetic agents such as metformin, sulfonylureas, thiazolidinediones, and insulin. |
| Лекарственные формы | Tablets (6.25 mg, 12.5 mg, 25 mg) for once-daily oral administration. Also available in combination with metformin or pioglitazone. |
| Администрация | Taken once daily, with or without food. Dose adjustments are required for patients with renal impairment (e.g., 12.5 mg daily for CrCl 30–60 mL/min, 6.25 mg daily for CrCl 15–30 mL/min, and 6.25 mg daily for CrCl <15 mL/min or on hemodialysis). |
| Фармакокинетика | – Half-life: Approximately 21 hours.<br>- Excretion: Primarily through urine (76%) and feces (13%). |
| эффективность | Alogliptin has been shown to significantly reduce HbA1c levels and improve fasting plasma glucose in clinical trials. It also has a neutral effect on body weight. |
| Безопасность | – Generally well-tolerated with a low risk of hypoglycemia.<br>- Common side effects include headache and nasopharyngitis.<br>- Caution is advised in patients with renal impairment due to the need for dose adjustment.<br>- No dose adjustment is required for hepatic impairment. |
| Память | Хранить при комнатной температуре, защищать от влаги. |
| химические свойства | – Molecular Formula: C18H21N5O2.<br>- Molecular Weight: 339.39.<br>- CAS Number: 850649-61-5.<br>- Solubility: Soluble in DMSO (68 mg/mL), water (2 mg/mL), and ethanol (60 mg/mL). |
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