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Код каталога 80020224
CAS NO.59-97-2
Чистота 99%
Номер MDLMFCD00012693
EINEC200-447-3
Molecular formula C10H12N2.HCl
Молекулярный вес 196.72
Температура плавления: 172~176°С
| категорию | Информация |
|---|---|
| химические свойства | – Molecular Formula: C₁₀H₁₃ClN₂<br>- Molecular Weight: 196.68 g/mol |
| Физические свойства | – Appearance: White crystalline solid.<br>- Melting Point: 172-176°C.<br>- Solubility: Soluble in water. |
| Механизм действия | – Acts as a non-selective and competitive α-adrenergic receptor antagonist.<br>- Exhibits vasodilatory effects, particularly in pulmonary circulation. |
| Клиническое использование | – Used as a pulmonary vasodilator in neonates with persistent pulmonary hypertension (PPHN) to reduce pulmonary vascular resistance.<br>- Investigated for other cardiovascular applications. |
| Условия хранения | Store at room temperature in an inert atmosphere. |
| Номер по CAS | 59-97-2 |
| Синонимы | – Tolazoline HCl.<br>- 2-Benzyl-2-imidazoline hydrochloride |
Имена и идентификаторы
| Имя | Толазолин гидрохлорид |
| Синонимы | Tolazoline HCl TIMTEC-BB SBB000360 2-BENZYL-2-IMIDAZOLINE Толазолин гидрохлорид BENZIDAZOL HYDROCHLORIDE BENZAZOLINE HYDROCHLORIDE 2-BENZYL-4,5-IMIDAZOLINE HCL 2-BENZYL-2-IMIDAZOLINE CHLORHYDRATE 2-BENZYL-2-IMIDAZOLINE HYDROCHLORIDE 2-BENZYL-2-IMINAZOLINE HYDROCHLORIDE 2-бензил-2-имидазолина гидрохлорид |
| CAS | 59-97-2 |
| EINECS | 200-447-3 |
| InChI | InChI=1/C10H12N2.ClH/c1-2-4-9(5-3-1)8-10-11-6-7-12-10;/h1-5H,6-8H2,(H,11,12);1H |
59-97-2 – Физико-химические свойства
| Молекулярная формула | C10H13ClN2 |
| Молярная масса | 196.68 |
| Температура плавления | 172-176 ° C |
| Болинг Точка | 338.2 ° C при 760 мм рт.ст. |
| Точка возгорания | 158.3 ° C |
| Растворимость | ДМСО (слегка нагретый), метанол (слегка) |
| Давление пара | 0.000196 мм рт. Ст. При 25 ° C |
| Внешний вид | Кристаллический порошок |
| Цвет | Белый почти белый |
| Merck | 14,9506 |
| Условия хранения | Инертная атмосфера, комнатная температура |
| Стабильность | гигроскопический |
| чувствительный | гигроскопический |
| MDL | MFCD00012693 |
| Используйте | Используется как сосудорасширяющее средство |
| Исследование in vitro | Tolazoline is a pulmonary vasodilator used to attenuate pulmonary vascular resistance (PVR) in neonates with persistent pulmonary hypertension (PPHN). Tolazoline has moderate alpha-adrenergic blocking activity and histamine agonist activity. Tolazoline is commonly used to reduce pulmonary artery pressure and vascular resistance. For all the spasmogenic drugs investigated, Tolazoline did not have a broad range of effects as did SNP. However, in the human radial artery, it may be effective in counteracting alpha-adrenergic receptor-mediated vasospasm. |
59-97-2 – Риск и безопасность
| Символы опасности | Xn – Вредный |
| Коды рисков | 22 – Вредно при проглатывании |
| Описание безопасности | 22 – Не вдыхайте пыль. |
| Идентификаторы ООН | 2811 |
| ЗКТВ | Да |
| Код ТН ВЭД | 29332900 |
| Токсичность | LD50 orl-rat: 1200 mg/kg NIIRDN 6,511,82 |
Tolazolin hydrochloride tablets
This product shall contain tolazoline hydrochloride (C10H12N2 • HCl) in an amount of 93.0% to 107.0% of the labeled amount.
особенность
This product is a sugar-coated tablet, which is white after removing the coating.
идентификация
Take 8 tablets of this product, grind, extract with ethanol for 3 times, 10ml each time, heat, filter, combine filtrate to dry, add water 10ml, dissolve, filter, filtrate to dry, the following tests were performed for residual ulcers.
- about 10mg of the residue was taken, and 1 ml of water was added to dissolve tolazoline hydrochloride, and several drops of a test solution of ammonium chromate thiocyanate were added to produce a pink precipitate.
- the aqueous solution of the residue showed the reaction of chloride identification (1) (General 0301).
экспертиза
should be in accordance with the relevant provisions under The tablet item (General rule 0101).
Определение содержания
- измерено методом высокоэффективной жидкостной хроматографии (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica as filler; Methanol-0.068% phosphoric acid solution [(50:50), the pH value was adjusted to 3.0 with ammonia solution. The detection wavelength was 230nm. The number of theoretical plates shall not be less than 1500 based on the calculation of tazolin peak.
- determination of 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 50mg equivalent to tolazoline hydrochloride), put in a 100ml measuring flask, add an appropriate amount of mobile phase, ultrasonic dissolution of tolazoline hydrochloride, dilute to scale with mobile phase, shake well, filter, Take 5ml of continued filtrate precisely, put it in 50ml measuring flask, dilute to scale with mobile phase, shake well, accurately measure 20ul, inject human liquid chromatograph, record the chromatogram; Take another reference substance of tolazoline hydrochloride, the mobile phase was added to dissolve and quantitatively dilute to prepare a solution containing about 50ug per 1 ml, which was determined by the same method. According to the external standard method to calculate the peak area, that is.
category storage
Same as tolazoline hydrochloride.
Спецификация
25mg
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