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Цитиколин натрия способен постепенно восстанавливать функцию конечностей при гемиплегии, вызванной мозговым инсультом, а также может применяться при других функциональных и сознательных расстройствах, вызванных острым повреждением центральной нервной системы, а также ишемической болезнью головного мозга и сосудистой деменцией.
Citicoline Sodium, also known as sodium citicoline, is a compound used in medicine and neuroscience research. It plays a crucial role in brain health and cognitive function due to its ability to enhance phospholipid metabolism in brain cell membranes.
Citicoline Sodium acts as a precursor for the synthesis of phosphatidylcholine, a major component of cell membranes. This process supports the structural integrity and fluidity of neuronal membranes, which are essential for optimal brain function. Additionally, Citicoline Sodium contributes to the production of acetylcholine, a neurotransmitter involved in memory and learning processes.
In clinical applications, Citicoline Sodium has been utilized for treating various neurological disorders such as stroke, traumatic brain injury, and dementia. Studies have shown that it can improve symptoms by promoting recovery of brain function and enhancing cognitive abilities. After administration, Citicoline Sodium is broken down into choline and cytidine, both of which cross the blood-brain barrier to exert their effects.
The safety profile of Citicoline Sodium is generally favorable when administered under medical supervision. However, like any pharmaceutical product, it may cause side effects in some individuals, including gastrointestinal discomfort or headache. Therefore, its use should be guided by healthcare professionals who consider individual patient needs and conditions.
Beyond clinical settings, Citicoline Sodium is also popular among healthy individuals seeking nootropic benefits—enhancements to memory, attention, and mental energy. Despite promising results from numerous studies, further research is necessary to fully understand its mechanisms and long-term effects.
In summary, Citicoline Sodium serves as an important tool in maintaining and restoring brain health through its impact on membrane repair and neurotransmitter synthesis. Its potential continues to be explored across different fields of medicine and beyond.
| категорию | Подробнее |
|---|---|
| Химическая формула | C₁₄H₂₆N₄NaO₁₁P₂ (Sodium salt of cytidine-5′-diphosphocholine) |
| Фармакологический класс | Neuroprotective agent– Enhances phospholipid biosynthesis in neurons |
| Основные показания | –Cerebrovascular accidents: Post-stroke recovery –Cognitive impairment: Alzheimer’s, vascular dementia –Head trauma: TBI rehabilitation –Glaucoma: Neuroprotective adjunct |
| Механизм действия | –Phospholipid precursor: Increases neuronal membrane synthesis –Acetylcholine precursor: Boosts cholinergic neurotransmission –Antioxidant: Reduces free radical damage |
| Фармакокинетика | – Биодоступность: ~15% (перорально) – Период полураспада: 1.5-3 часов –Metabolism: Hydrolyzed to choline/cytidine –Excretion: Renal (70-80%) |
| Лекарственные формы | – Таблетки: 500 мг, 1000 мг –Injections: 500mg/2mL, 1000mg/4mL –Oral solution: 50mg/mL |
| Администрация | –Acute phase: IV infusion (1000mg/day) –Maintenance: Oral (500-2000mg/day) –Duration: 6-12 weeks (clinical trials) |
| Побочные эффекты | –Mild: Headache, GI disturbance –Rare: Allergic reactions, hypotension –Long-term: Not established (limited data >6 months) |
| Лекарственное взаимодействие | –Synergistic: Levodopa, donepezil –Caution: Anticholinergics (additive effects) –Monitor: Warfarin (theoretical interaction) |
| Нормативный статус | –FDA: Dietary supplement (NDIN 883) –EMA: Orphan drug designation (2008) –Japan: Approved for dementia (2011) |
| Рыночные тренды | –Aging populations: Rising demand for cognitive enhancers –Combination therapies: With cholinesterase inhibitors –Emerging markets: Asia-Pacific growth (2023-2028 CAGR ~7.2%) |
Note: Clinically studied for neuroplasticity enhancement. Requires controlled trials to validate long-term efficacy in chronic neurodegeneration.
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