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Молекулярная формула: C13H20N2O2.
HCL Molecular Weight: 272.8
Номер CAS: 51-05-8
Имена и идентификаторы
| Имя | Прокаин гидрохлорид |
| Синонимы | cetain irocaine eugerase ethocaine bernocaine ATOXICAINE chlorocaine Прокаин Hcl TIMTEC-BB SBB001081 Прокаин гидрохлорид 2-(Diethylamino)ethyl 4-aminobenzoate 2-methylpropyl 4-aminobenzoate hydrochloride diethylaminoethanol4-aminobenzoatehydrochloride |
| CAS | 51-05-8 |
| EINECS | 200-077-2 |
| InChI | InChI=1/C13H20N2O2.ClH/c1-4-15(5-2)13(3,17)12(16)10-6-8-11(14)9-7-10;/h6-9,17H,4-5,14H2,1-3H3;1H |
| InChIKey | HCBIBCJNVBAKAB-UHFFFAOYSA-N |
51-05-8 – Физико-химические свойства
| Молекулярная формула | C13H21ClN2O2 |
| Молярная масса | 272.77 |
| Плотность | 1.1761 (приблизительная оценка) |
| Температура плавления | 155-156 ° С (горит.) |
| Болинг Точка | 195-196 ° C 17 мм |
| Точка возгорания | 195-196 ° С / 17mm |
| Растворимость воды | растворимый |
| Растворимость | Раствор S прозрачен (2.2.1) и бесцветен (2.2.2, Метод II). |
| Внешний вид | Кристаллы или кристаллический порошок |
| Цвет | Бесцветный до белого |
| Merck | 14,7757 |
| BRN | 3917802 |
| Условия хранения | 2-8 ° C |
| Стабильность | Стабильная. Несовместим с сильными окислителями. |
| чувствительный | Чувствительный к воздуху |
| Показатель преломления | 1.5270 (оценка) |
| Используйте | Local anesthetics for infiltration of local anesthesia, nerve block, etc |
| Исследование in vitro | Procaine acts primarily by inhibiting the influx of sodium ions through voltage-gated sodium channels on the cell membrane of neurons in peripheral nerves. When the internal flow of sodium ions is interrupted, the action potential cannot occur and the signal transmission is therefore inhibited. The receptor site is considered to be located in the cytoplasmic (internal) portion of the sodium channel. Procaine is also capable of binding to or antagonizing the function of the N-methyl-D-aspartate (NMDA) receptor and the nicotinic acetylcholine receptor and serotonin receptor-ion channel complex. Procaine is an inhibitor of calcium and caffeine-induced calcium release in various types of muscle preparations. 0.5 mM Procaine blockade of sarcoplasmic reticulum in individual lipid bilayers CaProcaine can be used as a DNA demethylating agent with inhibitory effect on the growth of human cancer cells. 0.5 mM Procaine was able to reduce 5-methylcytosine DNA by 40% in MCF-7 breast cancer cell lines. Procaine is also able to bind to CpG-enriched DNA, demethylating densely hypermethylated CpG sequences, resulting in epigenetically silenced genes restoring gene expression. Procaine treatment (0.5 mM) increased the mitotic index of cells in M-phase. Procaine treatment (1 mM) reduced cell proliferation by ~ 40%. Procaine affects the shape and deformability of red blood cells. 45 mM Procaine almost completely prevented the discoid cell-Acanthocyte conversion associated with ATP depletion. Similar concentrations of Procaine normalized ATP-depleted cell stickiness and filterability, but had no effect on cell volume, osmotic fragility, or monovalent cation composition. |
| Исследование in vivo | Procaine is a stimulant of the cells of the limbic system. In awake cats, 15 mg/kg Procaine increased cellular activity in the hippocampus ventral amygdala, nucleus accumbens, temporal neocortex, and ventromedial hypothalamus. Procaine promotes the conduction of evoked stimulatory activity from the amygdala to the ventromedial hypothalamus. sup> [8]Procaine affects the frequency and amplitude of rhythmic slowing activity in the hippocampus elicited as a network. Procaine (0.5 microliters, 20% weight/volume) is injected in the ascending system before the suprapillary nucleus, near the medial forebrain bundle or in the medial barrier area, it reduces the amplitude of hippocampal rhythmic slowing activity (RSA) elicited in the form of a reticular, with no effect on frequency. The injection of Procaine in the ascending system preceding the site of reticular stimulation, reaching, and including the suprapapillary nucleus, simultaneously reduced the frequency and amplitude of RSA elicited in the reticular form. In rats, Procaine (80 mg/kg) increased the duration and conduction range of post-epileptiform discharges (ADs) produced by electrical stimulation of the amygdala. Porcaine also increased seizure development (kindling) in rats produced by repeated amygdala stimulation. In adequately stimulated subjects, Procaine may also act as a convulsant. Procaine produced a weak but significant increase in the amplitude of the transcallosal evoked potentials. Procaine affects the production of auditory brainstem responses (ABRs). Procaine (30 microliters of 1% solution) was injected into the oblique body of guinea pigs, affecting many scalp-derived ABR components: N2 was delayed, the duration of P2 was longer, P3 and N3 disappeared, the latency of P4 is shortened, the duration becomes longer, the amplitude is not affected, and N4 is greatly attenuated. Only P1 and N1 were not affected by procaine injection. Procaine increases the therapeutic index of cisplatin by improving the antitumor activity of cisplatin and reduces its nephrotoxicity. In BDF1 mice, the combined administration of cisplatin and Procaine (40 mg/kg) produced 50% of the lethal dose (LD50) and 90% of the lethal dose (LD90) the value is almost 2-fold higher than that of cisplatin alone. The combined administration produced a higher cure rate than cisplatin alone (50% vs. 9%). After 4-7 days of cisplatin alone, increased blood urea nitrogen (BUN) levels were observed, as well as tubular degeneration detected by light microscopy, these phenomena were not observed when the same doses of cisplatin and Procaine were administered in combination. |
51-05-8 – Риск и безопасность
| Символы опасности | Т – Токсичный |
| Коды рисков | R25 – Токсично при проглатывании R43 – Может вызвать сенсибилизацию при контакте с кожей. R36/37/38 – Раздражает глаза, дыхательную систему и кожу. R23/24/25 – Токсично при вдыхании, попадании на кожу и проглатывании. |
| Описание безопасности | S36/37/39 – Носите подходящую защитную одежду, перчатки и средства защиты глаз/лица. S45 – В случае несчастного случая или плохого самочувствия немедленно обратитесь к врачу (по возможности покажите этикетку). S37/39 – Носите подходящие перчатки и средства защиты глаз/лица. S26 – При попадании в глаза немедленно промыть большим количеством воды и обратиться к врачу. |
| Идентификаторы ООН | UN 2811 6.1 / PG 3 |
| WGK Германия | 3 |
| RTECS | DG2275000 |
| ЗКТВ | Да |
| Код ТН ВЭД | 29242990 |
| Класс опасности | 6.1 |
| Группа упаковки | III |
| Токсичность | LD50 in mice (mg/kg): 660 ± 60 s.c. (Goldenthal) |
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