TEL
+ 86-21-6420 0566
C
Внешний вид: бесцветная прозрачная жидкость
Чистота: ≥99.5%
Мощность: 500 мт/год
Применение: органический промежуточный продукт
Упаковка: пластиковый/железный барабан 250 кг
Стандарт: экспорт предприятия
Производитель: Jinan Finer Chemical Co., Ltd.
Синонимы: HFIP
1.1.1.3.3.3-Гексафторизопропанол
1.1.1.3.3.3-Гексафторпропан-2-ол
Молекулярная формула: C3H2F6O
Молекулярный вес: 168.04
Номер CAS Registry: 920-66-1
EINECS: 213-059-4
HFIP используется в качестве промежуточного продукта в фармацевтической промышленности и в качестве промежуточного продукта в сельскохозяйственной химии.
HFIP можно использовать в качестве растворителя для очистки электронных устройств.
Благодаря своим свойствам HFIP может растворять большую часть полимеров, таких как полиэстер, полиамид, полиакрилонитрил, поливинилацеталь и гидролизованный поливиниловый эфир и т. д., что позволяет использовать его в анализе, а также в качестве агента для повторного использования и переработки полимеров.
Имена и идентификаторы
| Имя | 1,1,1,3,3,3-гексафтор-2-пропанол |
| Синонимы | HFIP C3H2F6O JACS-920-66-1 Гексафторизопропанол 2H-Hexafluoroisopropano 2-Пропанол, гексафтор- 2H-hexafluoro-2-propanol 2H-Hexafluoroisopropanol Hexafluoroisopropyl alcohol Bis(trifluoromethyl)methanol 1,1,1,3,3,3-hexafluoro-2-propano 1,1,1?,3,3-Hexafluoro-2-propanol 1,1,1,3,3,3-Гексафторизопропанол 1,1,1,2,3,3-hexafluoropropan-2-ol 1,1,1,3,3,3-гексафтор-2-пропанол Sevoflurane USP Related Compound C 2,2,2-Trifluoro-1-(trifluoromethyl)ethanol Ethanol, 2,2,2-trifluoro-1-(trifluoromethyl)- (2,3,4,5,6-pentafluorophenyl) pyrimidine-5-carboxylate 1,1,1,3,3,3-hexafluoro-2-propanolakahfip,hexafluoroisopropanol |
| CAS | 920-66-1 |
| EINECS | 213-059-4 |
| InChI | InChI=1/C11H3F5N2O2/c12-5-6(13)8(15)10(9(16)7(5)14)20-11(19)4-1-17-3-18-2-4/h1-3H |
| InChIKey | BYEAHWXPCBROCE-UHFFFAOYSA-N |
920-66-1 – Физико-химические свойства
| Молекулярная формула | C3H2F6O |
| Молярная масса | 168.04 |
| Плотность | 1.596 г/м при 25°C (лит.) |
| Температура плавления | −4°C(лит.) |
| Болинг Точка | 59 ° С (горит.) |
| Точка возгорания | 4,4 ° C |
| Растворимость воды | 1000 г / л (25 ºC) |
| Растворимость | Soluble in water (1000 mg/ml at 25 °C), chloroform, ether, and acetone. |
| Давление пара | 269 гПа (30 °C) |
| Внешний вид | Прозрачная жидкость |
| Удельный вес | 1.596 |
| Цвет | От белого до желтого |
| Максимальная длина волны (λmax) | ['229нм(лит.)'] |
| BRN | 1841007 |
| рКа | рК1:9.42 (25°С) |
| PH | 3-4 (H2O) Водный раствор |
| Условия хранения | Хранить ниже + 30 ° C. |
| Стабильность | Стабильный. Несовместим с сильными кислотами, сильными основаниями, щелочными металлами. |
| Показатель преломления | n20 / D 1.275 (освещен). |
| MDL | MFCD00011651 |
920-66-1 – Риск и безопасность
| Коды рисков | R20/22 – Вредно при вдыхании и проглатывании. R34 — Вызывает ожоги. |
| Описание безопасности | S26 – При попадании в глаза немедленно промыть большим количеством воды и обратиться к врачу. S36/37/39 – Носите подходящую защитную одежду, перчатки и средства защиты глаз/лица. S45 – В случае несчастного случая или плохого самочувствия немедленно обратитесь к врачу (по возможности покажите этикетку). S27 – Немедленно снимите всю загрязненную одежду. |
| Идентификаторы ООН | UN 2922 8 / PG 2 |
| WGK Германия | 2 |
| RTECS | UB6450000 |
| F-КОДЫ МАРКИ FLUKA | 27 |
| ЗКТВ | T |
| Код ТН ВЭД | 29055910 |
| Опасная нота | коррозионный |
| Класс опасности | 8 |
| Группа упаковки | II |
| Токсичность | LD50 перорально у кроликов: 1500 мг/кг |
920-66-1 –Reference
| ReferenceShow more | 1. Zhang Li Ling, Gao Tingting, Chen Shi Yu, etc. Preparation and characterization of oriented Poly (ε-caprolactone) mic… |
920-66-1 – Введение
Hexafluoroisopropanol is a special fluorine-containing material with high density, low viscosity and low surface tension. It is transparent under ultraviolet light (<2000A) and has a low refractive index. It can be miscible with water or most organic solvents in any proportion, but it is insoluble in long-chain alkanes. Solubility in water: 1000g/L (25°C)
920-66-1 – Справочная информация
| LogP | 1.5 при 25 ℃ |
| поверхностное натяжение | 67.1 мН/м при 1 г/л и 19.8 ℃ |
| Обзор | hexafluoroisopropanol (HFIP) is a viscous, pungent, colorless liquid. It is an ideal solvent for dissolving polyamides and esters and can be used for the analysis of nylon. Typically, a small amount of sodium trifluoroacetate can be added to the eluate to reduce aggregation of the sample. Although HFIP has a certain viscosity, its boiling point is very low, and it is usually required to analyze at 40°C to reduce the back pressure of the column. Hexafluoroisopropanol is also a highly polar solvent, which makes the calibration curve of mixed column column become nonlinear. Therefore, Agilent has developed a special chromatography column for this solvent-PL HFIPgel chromatography column, which has a porous structure that is not affected by the solvent. |
| Процесс подачи заявки | hexafluoroisopropanol (HFIP) is an important fluorine-containing fine chemicals, it can be used to prepare various fluorine-containing chemicals such as fluorine-containing surfactants, fluorine-containing emulsifiers, fluorine-containing medicines and the like, or as a good solvent. The efficiency of rhodium (I)-Catalyzed [4 2] intramolecular cycloaddition reaction of ether-bound alkynyl dienes and [5 2] cycloaddition reaction of alkynyl vinyl cyclopropane can be improved; liquid Phase peptide chemical solvents; Highly soluble solvents for peptides and peptide intermediates; For analysis of various polymers. |
| Процесс подачи заявки | hexafluoroisopropanol (HFIP) is a new type of fluorine-containing compound, which is a highly polar solvent, it is easy to mix with water and many organic solvents, has good thermal stability, and has good transmittance to ultraviolet light. These properties enable HFIP to be an ideal solvent in many polymerization systems: HFIP is an intermediate for use in pharmaceuticals, for the synthesis of the inhaled anesthetic sevoflurane, and for the synthesis of Agrochemicals: HFIP can be used as a solvent detergent in electronic aspects: HFIP can dissolve a large part of the polymer, such as polyester, polyamide, polyacrylonitrile, polyacetal and hydrolyzed polyvinyl Ester, etc, because of this property, it can be used in the analysis and as a regeneration agent for the reuse of high polymers. hexafluoroisopropanol can be used for the preparation of fluorine-containing surfactants, fluorine-containing emulsifiers, fluorine-containing pharmaceuticals and other high-end chemicals, and as a solvent or cleaning agent for the Electronic Industry fluorinated solvents, the efficiency of rhodium (I)-Catalyzed [4 2] intramolecular cycloaddition reaction of ether-bound alkynyl dienes and [5 2] cycloaddition reaction of alkynyl vinyl cyclopropane can be improved; liquid Phase peptide chemical solvents; Highly soluble solvents for peptides and peptide intermediates; For analysis of various polymers |
| метод синтеза | hexafluoroacetone (HFA, hexafluoroace-tone) catalytic hydrogenation reduction synthesis is usually used, and gas phase method or liquid phase method can be used. HFA, which is gaseous at normal temperature, is reacted with excess hydrogen in a tubular reactor under the action of a catalyst. The gas phase method has a fast reaction speed, but the reaction temperature is higher, and the side reaction is easy to occur. HFA combines with water to form hydrates with different water. The catalytic hydrogenation reaction of HFA hydrate in liquid phase can be carried out at lower temperature. The preparation of HFIP by catalytic reduction method requires the use of expensive catalysts, and HFA often contains a small amount of impurities such as hydrogen fluoride and hydrogen chloride, which easily leads to catalyst poisoning, thereby increasing the cost and reducing the reaction selectivity. 45kg of hexafluoroacetone hydrate (containing 1% catalyst) was input into a 50L reaction kettle, and the vacuum-nitrogen and nitrogen-hydrogen replacement were carried out successively. Hydrogen is introduced to normal pressure, heated to 100 ° C., stirring speed 30 rpm, hydrogen is introduced to 1MPa, and the reaction is carried out at constant pressure until there is no pressure drop for 1 hour. Reduce temperature and pressure, press out the material and filter. |
Фабрика и отгрузка
