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Фенилбороновая кислота, also known asBenzeneboronic acid, is an organoboron compound with a phenyl ring and a boronic acid group. This compound is a valuable building block in organic synthesis, material science, and pharmaceutical research due to its unique reactivity and structural properties.
Свойства ключа
| Объект | Подробнее |
|---|---|
| Название IUPAC | Фенилбороновая кислота |
| Номер по CAS | 98-80-6 |
| Молекулярная формула | C₆H₇BO₂ |
| Молекулярная масса | X |
| категорию | Boronic acid compound, Biochemical reagent |
| Внешний вид | Белое до не совсем белого твердого вещества |
| Точка кипения | ~ 265.9 ° С |
| Температура плавления | 216-219 ° C |
| Плотность | ~1.1 г/см³ |
| Растворимость | Soluble in ether and methanol, insoluble in water and benzene |
| Условия хранения | Sealed, in a cool, dry place, avoid contact with oxidants |
| Метод синтеза | Grignard reagent method, Reaction of benzene with ammonium borate |
| Приложения | Suzuki coupling reactions, Drug synthesis, Material science, Catalysis |
Синтез
Фенилбороновая кислотаcan be synthesized using various methods. One common approach involves the reaction of phenyl Grignard reagent with boron triester. Another method is the reaction of benzene with ammonium borate under acidic conditions to yield phenylboronic acid.
Приложения
В органическом синтезеФенилбороновая кислотаis a crucial reagent, particularly in Suzuki coupling reactions, where it is used to synthesize various substituted benzene compounds. These compounds play a vital role in drug and pesticide development.
The compound also finds applications in biochemistry, where it selectively binds to biological molecules such as sugars and amino acids. This property makes it useful in the development of biosensors and drug delivery systems.
Добавим, что, помимо вышесказанного, Фенилбороновая кислотаis used as a crosslinking agent in polymer synthesis, improving the mechanical properties and thermal stability of materials. It also serves as a catalyst in certain reactions, such as the conversion of alcohols and ketones.
Фабрика и отгрузка
