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Молекулярная формула: C25H28N6O
Молекулярный вес: 428.529
Номер CAS: 138402-11-6
| категорию | Подробнее |
|---|---|
| химические свойства | Molecular formula: C25H28N6O<br>Molecular weight: 428.53 g/mol |
| Механизм действия | Irbesartan is an angiotensin II receptor antagonist (ARB) that selectively blocks the AT1 receptor, reducing the vasoconstrictive and aldosterone-secreting effects of angiotensin II, thereby lowering blood pressure. |
| Терапевтическое Использование | повышенное кровяное давление: Used alone or in combination with other antihypertensive agents to lower blood pressure.<br>Диабетическая нефропатия: Reduces proteinuria and protects kidney function in patients with type 2 diabetes and hypertension.<br>Остановка сердца: Used as a second-line agent in the treatment of congestive heart failure. |
| Фармакокинетика | Поглощение: 60-80% bioavailable, with peak plasma concentrations reached in 1.5-2 hours.<br>Распределение: Volume of distribution is 53-93 L.<br>метаболизм: Metabolized primarily by CYP2C9 and glucuronidation.<br>экскреция: 20% excreted in urine, remainder in feces.<br>Период полураспада: Terminal elimination half-life is 11-15 hours. |
| Составы | Available as oral tablets in 75 mg, 150 mg, and 300 mg strengths. |
| Условия хранения | Хранить при комнатной температуре (68–77 °F; 20–25 °C), защищать от влаги. |
| Информация по технике безопасности | Generally well-tolerated. Side effects may include dizziness, headache, and fatigue. Use with caution in patients with renal or hepatic impairment. |
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