(3-Фтор-4'-Бутил – [1,1' – Бифенил] -4-ил) Борная кислота

(3-Fluoro-4′-butyl-[1.1′-biphenyl]-4-yl)boronic acidis a fluorinated biphenyl boronic acid derivative, representing a structural variation of the propyl-substituted analog. This compound features a fluorine atom at the meta position of one benzene ring and a butyl substituent on the adjacent ring, with the boronic acid group located at the para position relative to the butyl group. Such structural features offer unique electronic and steric properties, influencing its reactivity and potential applications.

Свойства ключа

While specific physical property data for the butyl derivative may be limited, it is reasonable to infer based on the propyl analog that this compound would exhibit similar characteristics. It is likely to appear as a white to off-white powder and be stable under normal conditions. The compound’s solubility in common organic solvents would facilitate its use in various reaction media. The presence of the fluorine atom and butyl group would impart distinct electronic and lipophilic properties, potentially affecting its biological activity and pharmacokinetics.

Синтез

Синтез(3-Fluoro-4′-butyl-[1.1′-biphenyl]-4-yl)boronic acidwould be analogous to that of the propyl derivative, involving palladium-catalyzed cross-coupling reactions such as the Suzuki-Miyaura coupling. This method would allow for the efficient construction of the biphenyl framework by coupling a fluorinated aryl halide with a butyl-substituted arylboronic acid.

Приложения

In organic synthesis, this compound would serve as a valuable building block for the preparation of complex molecules, particularly those requiring defined stereochemistry and functionality. Its fluorinated biphenyl structure would make it a promising candidate for the development of novel pharmaceuticals, agrochemicals, and functional materials. The boronic acid moiety could be further transformed into other functional groups, expanding the scope of its applications.

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