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Catalog : HY-125924CAS: 474922-26-4АспектПодробнееСтруктураDSPE-PEG consists of distearoylphosphatidylethanolamine (DSPE) and polyethyle...
Catalog : HY-125924
CAS: 474922-26-4
Аспект | Подробнее |
---|---|
Структура | DSPE-PEG consists of distearoylphosphatidylethanolamine (DSPE) and polyethylene glycol (PEG). DSPE provides hydrophobicity and membrane affinity, while PEG offers hydrophilicity and biocompatibility. |
Приложения | Widely used in drug delivery systems, such as liposomes and nanoparticles. It enhances stability, prolongs circulation time, and reduces immunogenicity. |
Функциональные группы | Available in various forms with different functional groups (e.g., -NH2, -COOH, -Mal) for conjugation with drugs, targeting ligands, or imaging agents. |
PEGylation Benefits | PEGylation improves water solubility, reduces protein adsorption, and enhances the stealth properties of drug carriers, allowing for longer circulation in the body. |
Целевая Доставка | Can be conjugated with targeting molecules (e.g., transferrin) to achieve targeted drug delivery, improving therapeutic efficacy and reducing side effects. |
Биомедицинская визуализация | Used in molecular imaging applications by conjugating with fluorescent dyes or radioactive labels to track drug carriers or diagnose diseases. |
Стабильность и совместимость | DSPE-PEG is stable in biological environments and compatible with various drug delivery formulations, making it suitable for both small and large molecule drug delivery. |
Нормативно-правовая база и безопасность | Generally recognized as safe (GRAS) for use in pharmaceuticals and medical devices due to its biocompatibility and low toxicity |
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