4-Chloro-7-toluenesulfonyl-7H-pyrrolo[2,3-D]pyrimidine Cas：479633-63-1

4-Chloro-7-toluenesulfonyl-7H-pyrrolo[2,3-D]pyrimidine (CAS No. 479633-63-1) is a compound with the molecular formula C13H10ClN3O2S and a molecular weight of 307.76 g/mol. It is primarily utilized as a pharmaceutical intermediate in the synthesis of selective Janus kinase 3 inhibitors (JAK3) and immunosuppressive drugs, such as tofacitinib. The compound’s structure features a substituted pyrrole ring and a toluene sulfonyl group, which may confer unique chemical properties and reactivity.

In drug development, this intermediate may undergo multi-step organic synthesis reactions, such as substitution and condensation, to introduce various pharmacophoric groups, thereby generating drug candidates with therapeutic potential. Although direct pharmacological data on this compound are currently limited, its role as a pharmaceutical intermediate suggests that the final product may possess immunosuppressive activity, particularly for the treatment of inflammatory diseases. Research on this compound in the fields of chemical synthesis and drug discovery continues, highlighting its potential applications in the pharmaceutical industry. Additionally, it is used as an impurity control in biochemical studies and for drug declaration testing.

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