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Номер CAS: 108-10-1
Молекулярная формула: C6H10O
Молекулярный вес: 98.14 г / моль
Внешний вид: от бесцветной до бледно-желтой жидкости.
Температура кипения: 102-104 °C
Плотность: 0.81 г / мл при 25 ° C.
Usage: Used as a solvent for coatings and resins, an intermediate in pharmaceuticals and pesticides, and a raw material for the production of methyl isobutyl ketone and methyl isobutyl alcohol.
| Атрибут | Информация |
|---|---|
| Химическое название | Оксид мезитила |
| Синонимы | 2.4.6-Trimethyloxirane, Trimethylethylene oxide |
| Номер по CAS | 108-10-1 |
| Молекулярная формула | C6H10O |
| Молекулярная масса | X |
| Физическое состояние | Бесцветная или слегка желтоватая жидкость |
| Точка кипения | 106-108 ° C |
| Плотность | 0.907 г/мл при 25°C |
| Показатель преломления | 1.426-1.428 |
| Растворимость | Miscible with organic solvents, slightly soluble in water |
| Точка возгорания | 12°C (закрытая чаша) |
| химические свойства | Epoxide; undergoes ring-opening reactions, reacts with acids to form esters |
| Приложения | Solvent in organic synthesis, intermediate in perfume and pharmaceutical production |
| Классификация опасностей | Flammable liquid, harmful if swallowed or inhaled |
| Влияние на здоровье | May cause respiratory irritation, skin and eye irritation |
| Меры предосторожности | Store in a cool, well-ventilated area, keep away from heat and open flames, wear protective equipment when handling |
| Распоряжение | Утилизировать в соответствии с местными правилами и рекомендациями по утилизации опасных отходов. |
Имена и идентификаторы
| Имя | 4-Метил-2-пентанон |
| Синонимы | МИБК Гексон Изопропилацетон 4-Метил-2-пентанон 4-метилпентан-2-он Methyl isobuty ketone Methyl isobutyl keton Изобутилметилкетон Метилизобутилкетон MethylIsobutylKetoneAcs Methyl-Iso-ButylKetoneGr 4-METHYL-2-PENTANONE, FOR GC METHYL ISOBUTYL KETONE GC STANDARD Methyl-Iso-ButylKetone(Iso-ButylMethylKetone) |
| CAS | 108-10-1 |
| EINECS | 203-550-1 |
| InChI | InChI=1/C6H12O/c1-5(2)4-6(3)7/h5H,4H2,1-3H3 |
108-10-1 – Физико-химические свойства
| Молекулярная формула | C6H12O |
| Молярная масса | 100.16 |
| Плотность | 0.801 г / мл при 25 ° C (лит.) |
| Температура плавления | -80 °С (лит.) |
| Болинг Точка | 117-118 ° C |
| Точка возгорания | 56 ° F |
| Номер JECFA | 301 |
| Растворимость воды | 17 г / л (20 ºC) |
| Растворимость | вода: растворимая20g / л |
| Давление пара | 15 мм рт.ст. (20 ° C) |
| Плотность пара | 3.5 (против воздуха) |
| Внешний вид | жидкость |
| Цвет | APHA: ≤15 |
| запах | Pleasant; mild, characteristic; sharp; non-residual; ketonic. |
| Предел воздействия | TLV-TWA 205 mg/m3 (50 ppm); STEL 300mg/m3 (75 ppm) (ACGIH); IDLH 3000 ppm(NIOSH). |
| Максимальная длина волны (λmax) | ['λ: 335 нм Aмакс: 1.00', , ‘λ: 340 nm Amax: 0.50’, , ‘λ: 360 nm Amax: 0.15’, , ‘λ: 38 |
| Merck | 14,5207 |
| BRN | 605399 |
| Условия хранения | Хранить при + 5 ° C до + 30 ° C. |
| Предел взрываемости | 1.2-8%, 93 ° F |
| Показатель преломления | n20 / D 1.395 (освещен). |
| Физические и химические свойства | Colorless or pale yellow oily liquid. Melting point 12.39 ℃(11 ℃), boiling point 211.9 ℃(213-214 ℃),84.3 ℃(1.33kPa), relative density 1.2483(20/4 ℃), refractive index 1.5662. Flash point 87. Slightly soluble in water, soluble in ethanol, ether, acetone and benzene. There is a strong aldehyde odor. |
| Используйте | Used as pharmaceutical, dye intermediates. The dead Net of pesticide mites produced by O-chlorobenzaldehyde can control the mites on dry crops and fruit trees. O-chlorobenzoxime can be obtained by O-chlorobenzoxime oximation, and O-chlorobenzoxime can be obtained by further chlorination, which are all drug intermediates. |
108-10-1 – Риск и безопасность
| Коды рисков | R11 – Легковоспламеняющийся R20 – Вредно при вдыхании. R36/37 – Раздражает глаза и дыхательную систему. R66 – Повторное воздействие может вызвать сухость и растрескивание кожи. Р39/23/24/25 – R23/24/25 – Токсично при вдыхании, попадании на кожу и проглатывании. |
| Описание безопасности | S9 – Хранить контейнер в хорошо проветриваемом месте. S16 – Хранить вдали от источников возгорания. S29 – Не выливать в канализацию. S45 – В случае несчастного случая или плохого самочувствия немедленно обратитесь к врачу (по возможности покажите этикетку). S36/37 – Надевайте подходящую защитную одежду и перчатки. S7 – Держите контейнер плотно закрытым. |
| Идентификаторы ООН | UN 1245 3 / PG 2 |
| WGK Германия | 1 |
| RTECS | SA9275000 |
| ЗКТВ | Да |
| Код ТН ВЭД | 2914 13 00 |
| Класс опасности | 3 |
| Группа упаковки | II |
| Токсичность | LD50 перорально у крыс: 2.08 г / кг (Смит) |
108-10-1 – Добывающая и перерабатывающая промышленность
| сырье | Ацетон Водород |
| Перерабатывающие продукты | 4-Метил-2-пентанон N-1,3-dimethylbutyl-N’-phenyl-p-phenylenediamine 2,2′-Azobisisoheptonitrile |
Справочная информация
| FEMA | 2731 | 4-METHYL-2-PENTANONE |
| olfactory Threshold | 0.17ppm |
| Константа закона Генри | 2.56 at 25 °C (batch stripping method-GC, Kim et al., 2000) |
| LogP | 1.3-1.9 at 20℃ |
| (МАИР) классификация канцерогенов | 2Б (Том 101) 2013 |
| Введение | 4-methyl-2-pentanone (methyl isobutyl ketone) reagent, widely used in chemical and pharmaceutical solvents, separation and recovery of nuclear fission products and scientific research experiments. Commercially available 4-methyl-2-pentanone has a content of ≤ 99% and contains small amounts of alcohol, acidic substances, and impurities such as water. 4-methyl -2-pentanone is used as a solvent for nitrocellulose, paints and certain polymers and resins, and also for the synthesis of 2-(1-hydroxy-3-methylbutenes)-Reaction of 1H-indene-1, 3(2H)-Dione. |
| Анализ содержания | the content analysis method in “acetaldehyde (03401)” was used. The amount of the sample was 1.2g. The reaction time was changed to 60 min. Each Ml of 0.5 mol/L sulfuric acid solution corresponds to 50.08 mg of 4-methyl-2-pentanone (C6H12O). |
| токсичность | GRAS(FEMA).LD50 2080 mg/kg (rat, oral). |
| лимит использования | FEMA(mg/kg): Soft drink 6.3; Cold drink 6.3; Candy 6.3; Baked goods 6.3. Moderate limits (FDA § 172.515,2000). |
| Используйте | 4-methyl-2-pentanone, also known as methyl isobutyl ketone, is an intermediate of rodenticide. It is used as intermediate of medicine and dye. The dead Net of pesticide mites produced by O-chlorobenzaldehyde can control the mites on dry crops and fruit trees. O-chlorobenzoxime can be obtained by O-chlorobenzoxime oximation, and O-chlorobenzoxime can be obtained by further chlorination, which are all drug intermediates. A solvent such as nitrocellulose, resin, and gum. Extractants for certain inorganic salts. Organic synthesis used as standard substance, solvent and extractant for chromatographic analysis used as solvent, also used as dewaxing agent for lubricating oil perfume. Mainly used in the preparation of rum, cheese and fruit flavor. The product is an excellent medium boiling point solvent. It is used as a mineral dressing agent, a solvent for oil dewaxing, a color former for color film, and also used as a solvent for tetracycline and pyrethroid and DDT, an adhesive, a rubber glue, a coating paint for aircraft and models. It is also an effective separating agent for some inorganic salts: plutonium can be separated from uranium, niobium from tantalum, and zirconium from hafnium. Its peroxide is a very important initiator in the polymerization of polyester resin. It is also used in the organic synthesis industry. It is also useful as an anticoagulant and diluent for ethylene-based resins. |
| способ производства | is obtained from the catalytic selective hydrogenation of isopropyl acetone. 1t product consumed about 1220kg of isopropyl acetone and 550 of hydrogen. Another production process is the acetone one-step process. Liquid acetone was preheated in a fixed-bed reactor in the presence of KON-AL2O3-Pb, Mg-SiO-Pb, cation exchange resin-Palladium, zirconium phosphate-bar and copper-chromium dual-function catalysts, dehydration and hydrogenation reactions produce MIBK. This method has the advantages of short flow, small investment, high conversion rate and low cost. The largest MIBK unit in China was produced by Jinling petrochemical and chemical fertilizer plant in cooperation with Tianjin University by using acetone one-step method in February of 95, and the purity of the product reached 99%. It can also be obtained by condensation of isopropanol at normal pressure. It is obtained by mild hydrogenation of isopropylacetone over a nickel catalyst at 160-190 °c. Obtained by oxidation of methyl isobutyl methanol. The preparation method includes an isopropyl alcohol method and an acetone method. (1) isopropyl alcohol method Isopropyl alcohol is used as a raw material, and Isopropyl alcohol is dehydrogenated to acetone by an aluminum copper catalyst at normal pressure and a temperature of 180 to 220 ° C., followed by condensation with isopropyl alcohol and dehydration to obtain a product. (2) acetone method the acetone is heated, the vapor is passed through the sodium hydroxide catalyst, and the reaction is obtained under the normal pressure. The dipropanone is subjected to dehydration reaction in the presence of a phosphoric acid catalyst to obtain isopropene acetone, and the isopropene acetone is catalytically hydrogenated in the presence of a copper catalyst at a temperature of 170-200 ° C. To obtain a product. |
| Каталог | горючая жидкость |
| степень токсичности | отравление |
| Острая токсичность | Перорально-крыса LD50: 2080 мг/кг; Перорально-мышь LD50: 2671 мг/кг |
| данные стимуляции | Skin-rabbits 500 mg/24 h mild; eye-rabbit 500 mg/24 h mild |
| Характеристики взрывоопасности | взрывоопасен при смешивании с воздухом |
| характеристики опасности воспламеняемости | open flame, combustible heat and oxidant; Combustion emission stimulus smoke |
| Характеристики хранения и транспортировки | The warehouse is ventilated and dried at low temperature, separate from oxidants and acids |
| огнетушащее средство | water mist, foam, carbon dioxide, 1211 fire extinguishing agent |
| Профессиональный стандарт | TLV-TWA 50 PPM (205 мг/м3); Tel 75 PPM (300 мг/м3) |
| температура самовозгорания | 840°Ф. |
| immediate life-and health-threatening concentration | 500 частей на миллион |
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