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CAS № 9004-67-5
Имена и идентификаторы
| Имя | Метилцеллюлоза |
| Синонимы | MC адульсин Метоцел метилцеллюлозы Метилцеллюлоза walsrodermc20000s 'ТИЛОЗА'(R) MH 300 МОДИФИЦИРОВАННАЯ ЦЕЛЛЮЛОЗА 'ТИЛОЗА'(R) MH 1000 МОДИФИЦИРОВАННАЯ ЦЕЛЛЮЛОЗА, MC МЕТИЛОВЫЙ ЭФИР ЦЕЛЛЮЛОЗЫ Метиловый эфир целлюлозы Целлюлоза, метиловый эфир Метилцеллюлоза, вязкость 8000 сПз (6S)-3,4,5-trimethoxy-2-(methoxymethyl)-6-[(3R)-4,5,6-trimethoxy-2-(methoxymethyl)tetrahydropyran-3-yl]oxy-tetrahydropyran |
| CAS | 9004-67-5 |
| EINECS | 232-674-9 |
| InChI | InChI=1/C12H20O10/c1-21-9-11-13(23-3)15(24-4)18(27-7)20(30-11)31-14-12(10-22-2)29-19(28-8)17(26-6)16(14)25-5/h11-20H,9-10H2,1-8H3/t11?,12?,13?,14-,15?,16?,17?,18?,19?,20+/m1/s1 |
9004-67-5 – Физико-химические свойства
| Молекулярная формула | C20H38O11 |
| Молярная масса | 454.50912 |
| Плотность | 1.01 г/см3 (температура: 70 °C) |
| Температура плавления | 290-305 ° C |
| Болинг Точка | 507 ° C при 760 мм рт.ст. |
| Точка возгорания | 196.3 ° C |
| Растворимость воды | РАСТВОРИМЫ В ХОЛОДНОЙ ВОДЕ |
| Растворимость | Soluble in glacial acetic acid, slowly soluble in cold water and expand into viscose solution, insoluble in acetone, alcohol, ether, toluene, chloroform and hot water. |
| Давление пара | 6.67E-10 мм рт. Ст. При 25 ° C |
| Внешний вид | Белый порошок |
| Цвет | Белый, желто-белый или серовато-белый |
| Merck | 14,6040 |
| Условия хранения | Комнатная температура |
| Стабильность | Стабильная. Несовместим с сильными окислителями, отбеливателем, хлорной кислотой, азотной кислотой, перхлоратами, щелочными нитратами, щелочными нитритами, оксидом кальция. |
| чувствительный | Легко впитывает влагу |
| Показатель преломления | 1.469 |
| MDL | MFCD00081763 |
| Физические и химические свойства | A cellulose methyl ether. White or light yellow or light gray small particles (95% through a 40-mesh sieve), filaments or powder. Odorless and tasteless. It’s hygroscopic. The apparent density is 0.3~0.7g/m1. When all R in the structure is methyl, its degree of substitution is equal to 3, and the methoxy content accounts for 45.57%. Methyl cellulose used as a food additive, its methoxy content should be between 26% and 33%, and its corresponding displacement degree should be 1.7 to 2.2. When the degree of displacement is lower than 1.3, it is soluble in alkali, and when it is more than 2.6, it is soluble in organic solvent. It is soluble in cold water, pyridine, aniline, trimethylformamide, benzyl alcohol and glacial acetic acid between 1.3 and 2.6. The aqueous solution is stable at neutral and normal temperature, while at high temperature it produces gelling and precipitation. The gelling temperature depends on the viscosity and concentration of the solution, and the gelling temperature is lower when the viscosity and concentration are large. The presence of inorganic salts can increase the viscosity. Because it is a non-ionic solution, polyvalent metals cannot make it precipitate. Only when the electrolyte concentration and other dissolved substances exceed a certain limit, the gel effect will occur. The aqueous solution is surface active. After drying, it forms a thin film. After heating and cooling, it undergoes a reversible transition from sol to gel. |
| Используйте | This product can be used as a sizing agent for textile printing and dyeing, a synthetic resin dispersant, a coating film-forming agent, and a thickener. In the printing and dyeing industry, the original paste used for two-phase printing with vat dyes and reactive dyes requires the use of sodium hydroxide and caustic soda to reduce the vat dyes into a colorless substance before they can be dyed. |
9004-67-5 – Риск и безопасность
| Описание безопасности | 24/25 – Избегайте контакта с кожей и глазами. |
| WGK Германия | 3 |
| RTECS | FJ5959000 |
| F-КОДЫ МАРКИ FLUKA | 3 |
| ЗКТВ | Да |
| Код ТН ВЭД | 39129000 |
Справочная информация
| FEMA | 2696 | МЕТИЛЦЕЛЛЮЛОЗА |
| Обзор | methyl cellulose, also known as cellulose methyl ether, abbreviated as MC (abbreviation of methyl cellulose), is a long-chain replacement cellulose. The average molecular weight of methyl cellulose is 10,000~220,000, white powder or fibrous matter at room temperature, non-toxic, no irritation, no allergic effect, apparent relative density of 0.35~0.55 (truth density of 1.26~1.30). Swelling in water into a translucent viscous colloidal solution, the litmus is neutral, insoluble in ethanol, ether and chloroform, soluble in acetic acid. Acid, alkali, microbial, heat, light, etc., are not affected by oil and grease, but will burn when it reaches the ignition point. |
| Процесс подачи заявки | methylcellulose is widely used in the construction industry as a binder for cement, mortar, joint desliming, etc. It is used as film-forming agent and adhesive in cosmetics, medicine and food industry. It is also used as textile sizing agent, synthetic resin dispersant, coating film forming agent and thickener. The alkali cellulose is prepared from the pulp, and the alkali cellulose is reacted with methyl chloride or dimethyl sulfate in an autoclave, and then refined with warm water. |
| Свойства и приложения | methylcellulose is widely used in various oral and topical preparations, it is also widely used in cosmetics and food. Methylcellulose cannot be digested or absorbed after oral administration and is therefore a non-caloric material. Excessive intake of methylcellulose may temporarily increase flatulence and cause esophageal obstruction if the amount of drinking water is insufficient, but methylcellulose has a laxative effect. methyl cellulose is a hydrophilic colloid, is a highly viscous derivative of cellulose, non-toxic and irritating, with hygroscopicity, in cold water to expand into colloidal suspension, insoluble in hot water, alcohol, ether, chloroform and saturated salt solution. Dissolved in glacial acetic acid and the same amount of mixed alcohol and chloroform solution. The solution can be condensed by salt, polybasic acid, phenol and tannin, and can be prevented by adding ethanol. Methylcellulose is not digested and absorbed in the intestinal lumen. Itself can absorb water, mixed with water to form a large volume of hydrophilic jelly, increase the volume of feces, to soften, and can stimulate intestinal peristalsis, and promote defecation. In Diarrhea of patients, this product can absorb water, reduce the mobility of feces in the intestine, and play a role in stopping diarrhea. Oral 1~4G/d, and at the same time a large amount of drinking water, can be used as a volume of laxatives, for the treatment of constipation. This product has been used as an anorexia agent for appetite control, weight loss, but the effect is not reliable. Methyl Cellulose can be used as: adhesive, preferably low or medium viscosity grade glue, adding powder or solution can be used to improve the disintegration or dissolution rate of drugs; General concentration of 1% ~ 2%. Gel, thickening gel and cream, preferably high viscosity grade. Suspending agent and thickening agent, the solution can replace the syrup, thickening with a concentration of up to 5%. Tablet coating, can be applied to high displacement low viscosity grade film coating; Can also be used as a coating, coated on the outer core as a separation layer. Disintegrating agent, commonly used concentration is 2%~ 10%. Emulsifier, should choose low viscosity grade, the general concentration of 1% ~ 5%. Eye drops, should choose high viscosity grade. information editor: Andrew (chemical book). |
| stability and storage conditions | methylcellulose powder is stable, slightly hygroscopic, and should be placed in an airtight container, store in a cool and dry place. The methyl cellulose solution is stable to dilute acids and bases with pH values of 3 to 11 at room temperature, and is easily destroyed by microorganisms and putrefied. Therefore, the solution should be added with a preservative or autoclaved. The change of solution viscosity after autoclaving was related to the pH value of solution. For solutions with pH <4, the viscosity decreased by more than 20% after autoclaving. |
| несовместимость | methylcellulose has incompatibility with amacridine hydrochloride, chlorocresol, mercuric chloride, phenol, resorcinol, P-aminobenzoic acid, etc. Inorganic acid salt, phenol, tannic acid can make methyl cellulose coagulation; And tetracaine, sulfuric acid in the occurrence of complex. There is a combination of parabens, the use of parabens should be increased. |
| Анализ содержания | the content of methoxy group was determined according to the method in GT 14. |
| токсичность | ADI is not specified (FAO/WHO,2001). GRAS(FDA,§ 182.1480,2000). |
| Использовать лимит | FAO/WHO(1984) canned citrus 10mg/kg (used as anti-turbidity agent); cold drink 10 g/kg. According to Japanese regulations (1990), the maximum dosage is 2% (alone or in combination with calcium carboxymethyl cellulose, sodium carboxymethyl cellulose, sodium carboxymethyl starch, sodium starch phosphate). Still used as emulsion stabilizer of ice cream, the amount of 0.05%; Salad sauce 0.75%; Bread to prevent aging, such as surface homogenization 0.2% ~ 0.3%. For citrus canned to prevent the precipitation of hesperidin, juice as anti-white turbidity agent to add 10~30mg/kg. |
| Используйте | thickeners; Stabilizers; Emulsifiers; Excipients; Dispersants; Binders; Film formers hydrosol substitutes. Also used in mayonnaise, shortening and some other foods. Because this product is not digested in the body, can maintain several times of water, resulting in a sense of satiety, can be used to comb biscuits, waffle and other made into efficacy of food. When used, the powder is first moistened with about 1/5 of the required amount of water, followed by additional cold water (ice may be added if necessary) and stirred evenly. EEC: used for frozen foam products, potato chips, soft drinks, special dietary foods, baked goods filling, foaming top material, sauce, sauce. This product is widely used in the construction industry. Such as the use of cement, mortar, joint cement, etc. It is used as an adhesive for film-forming agents in cosmetics, pharmaceuticals, and food industries, and is also used as a sizing agent for textile printing and dyeing, a synthetic resin dispersant, a coating film-forming agent, and a thickener. Methyl fiber is a very stable material, can resist acid, alkali, microorganism, heat and so on. In the human body, completely unchanged and excreted in vitro. used as synthetic resin dispersant, coating film forming agent, thickener, building material adhesive, textile dyeing and dyeing sizing agent, pharmaceutical and food industry film forming agent, etc. thickener; Stabilizer; Emulsifier; Excipient; dispersant; Adhesive; Film-forming agent hydrosol substitute. Also used in mayonnaise, shortening and some other foods. Because this product is not digested in the body, can maintain several times of water, resulting in a sense of satiety, can be used to comb biscuits, waffle and other made into efficacy of food. First of all, wet the powder with about 1/5 of the water required, Add additional cold water (ice may be added if necessary) and stir evenly. EEC: used for frozen foam products, potato chips, soft drinks, special dietary foods, baked goods filling, foaming top material, sauce, sauce. bone marrow cells were cultured in semi-solid methylcellulose medium by pulse-field capillary electrophoresis on thousands of nucleotides in dilute methylcellulose solution. Used in the pharmaceutical industry as protective colloids and dispersants, extenders, stabilizing and emulsifying agents, adhesives. The aqueous suspension is neutral to litmus paper, and has different types of molecular weight of 4000~180000, generally containing 25 ~ 30% methoxy groups. Solubility: This product can dissolve in cold water, forming a transparent viscous solution. Because it contains a certain amount of hydrophobic groups, so this product can be dissolved in some organic solvents, but also soluble in water and organic mixed solvent. Salt resistance: This product is a non-ionic and non-polymeric electrolyte, therefore, it is relatively stable in aqueous solution of metal salts or organic electrolytes. Gelation or precipitation may be caused in case of excess electrolyte. Surface activity: this water solution has surface activity, with the function of colloid protective agent, emulsifier and dispersant. Thermal gelation: when heated to a certain temperature, the aqueous methyl cellulose solution becomes an opaque solution due to gel or precipitation. However, it gradually cools down and then changes to the original solution state. The temperature at which coagulation and precipitation occur depends on the type of product, the concentration of the solution and the heating rate. Low ash content: using the thermal gel properties of this product, hot water washing is used in the preparation process, so as to achieve the purpose of refining, so its ash content is very low. Incompatibility: acridine hydrochloride, chloro-cresol, mercuric chloride, phenol, ralzocin, tannic acid, silver nitrate, decahexyl pyridyl hydrochloride, P-Hydroxybenzoic acid, P-aminobenzoic acid, P-hydroxy |
| способ производства | alkali fiber is prepared from pulp and then etherified with methyl chloride. Pulp according to different sources, there are cotton pulp, wood pulp, straw pulp, industry is usually used in wood pulp and cotton pulp (cotton linter). Cellulose in pulp itself is difficult to methyl chloride, must first be made into alkali cellulose. Mix 1 part of cellulose, 0.9-1.2 parts of sodium hydroxide with 0.9-1.2 parts by weight of water, and soak for 1-2H at about 30 °c. The excess alkali solution was then removed by pressing to obtain the agglomerated alkali cellulose. The alkali cellulose tissue is crushed, and the alkali cellulose tissue is loose and further homogenized, and the oxygen in the air is reacted. The degradation of the alkali cellulose reduces the polymerization, and the purpose of adjusting the viscosity of the product is achieved. The alkali cellulose of the aging process is suspended in excess methyl chloride (generally 10-15 times the weight of the pulp), and the etherification can be completed by reacting at 60-70 ℃ for about 5H, the corresponding reaction pressure was about 1.7MPa. Post-treatment of the product includes washing and drying of the finished product. Generally, it is washed in hot water at 80-90 ℃, neutralized by adding appropriate amount of hydrochloric acid (or sulfuric acid), and oxalic acid is added to complex with iron and heavy metals, the water is removed along with salts such as sodium chloride. The washed product is dehydrated and dried to obtain a finished methyl cellulose product. wood pulp or cotton was treated with alkali, and alkali cellulose was methylated with methane chloride. Certain commercial articles contain small amounts (up to 5%) of Hydroxyethyl and/or hydroxypropyl substituted cellulose. For these products, The content indicator shall be calculated as% methoxy plus% ethoxy and/or propoxy and expressed as “total alkoxy” content. |
| категорию | Подробнее |
|---|---|
| Основная информация | |
| Имя | Метилцеллюлоза (MC) |
| Химическая формула | (C6H7O2(OH)2OCH3)n |
| Номер по CAS | 9004-67-5 |
| Тип | Эфир целлюлозы |
| Физические свойства | |
| Внешний вид | White or slightly off-white, odorless, tasteless, fibrous or powdered solid |
| Растворимость | Soluble in cold and hot water, forming a colloidal solution; insoluble in organic solvents |
| Вязкость | Varies depending on grade and concentration; higher grades and concentrations result in higher viscosity |
| химические свойства | |
| Стабильность | Stable under normal conditions; not sensitive to pH changes within a wide range |
| реактивность | Non-reactive with most chemicals; forms stable emulsions and suspensions in water |
| Приложения | |
| Фармацевтическая индустрия | Used as a binder, emulsifier, suspending agent, and stabilizer in tablets, capsules, and suspensions |
| Пищевая промышленность | Used as a thickener, stabilizer, and emulsifier in dairy products, baked goods, ice creams, and sauces |
| Косметика | Used as a stabilizer, thickener, and emulsifier in creams, lotions, and gels |
| Краски и покрытия | Provides viscosity and stability to water-based paints and coatings |
| Текстильная промышленность | Used as a sizing agent and thickener in textile printing |
| Строительство | Used in cementitious mortars and plaster to improve workability and water retention |
| Меры предосторожности | |
| Управляемость | Wear appropriate protective clothing and avoid contact with skin and eyes |
| Память | Store in a cool, dry place, away from direct sunlight and sources of ignition |
| Токсичность | Generally considered non-toxic; however, ingestion of large amounts may cause digestive discomfort |
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