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L-Norvaline: A Comprehensive Overview
1. Chemical & Structural Profile
| Атрибут | Подробнее |
|---|---|
| Формула | C₅H₁₁NO₂ |
| Молярная масса | X |
| классификация | Non-proteinogenic α-amino acid; structural analog of L-Valine |
| Ключевой особенностью | Branched-chain aliphatic structure with terminal amino group |
2. Biological Activity & Mechanisms
| Функция | Экшн |
|---|---|
| Arginase Inhibition | Competitively blocks arginase, increasing arginine bioavailability for NO synthesis |
| Сосудорасширяющий эффект | Enhances endothelial NO production, promoting vasorelaxation |
| Метаболическая роль | Modulates urea cycle efficiency; studied in ammonia detoxification pathways |
3. Therapeutic Implications
| Процесс подачи заявки | База доказательств |
|---|---|
| Сердечно-сосудистый | Preclinical studies show improved endothelial function in hypertensive models |
| Эректильная дисфункция | Phase II trials suggest efficacy as phosphodiesterase-5 inhibitor adjunct |
| Упражнение Производительность | Limited research indicates potential to enhance muscle pump via vasodilation |
4. Dosage & Considerations
| Параметр | Инструкции |
|---|---|
| Типичная доза | 100-500 mg/day (varies by indication) |
| Администрация | Oral capsules/tablets with meals for bioavailability |
| Противопоказания | Pregnancy/lactation caution; monitor in renal impairment |
| Лекарственное взаимодействие | May potentiate nitrates/sildenafil; avoid with arginine supplements |
Фабрика и отгрузка
