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Номер CAS 95-53-4
Содержание 99.50%
Упаковка 200 кг/бочка 1000 кг/IBC
Имена и идентификаторы
| Имя | о-толуидин |
| Синонимы | OT CP CI 37077 о-толуидин 2-толуидин 2-Aminotoluene Ortho Toluidine 2-метиланилин 2-methyl-anilin 2-methylbenzamine 2-methylbenzenamine o-toluidine solution 1-Methyl-2-aminobenzene 2-Methyl-1-aminobenzene 1-Amino-2-methylbenzene O-TOLUIDINE OEKANAL, 250 MG O-TOLUIDINE, STANDARD FOR GC |
| CAS | 95-53-4 |
| EINECS | 202-429-0 |
| InChIKey | RNVCVTLRINQCPJ-UHFFFAOYSA-N |
95-53-4 – Физико-химические свойства
| Молекулярная формула | C7H9N |
| Молярная масса | 107.15 |
| Плотность | 1.008 г / мл при 25 ° C (лит.) |
| Температура плавления | -23 ° C |
| Болинг Точка | 199-200 ° С (горит.) |
| Точка возгорания | 185 ° F |
| Растворимость воды | 1.5 г / 100 мл (25 ºC) |
| Растворимость | 1.5 г / 100 мл (25 ° C) |
| Давление пара | 0.26 мм рт.ст. (25 ° C) |
| Плотность пара | 3.7 (против воздуха) |
| Внешний вид | жидкость |
| Цвет | от светло-желтого до светло-янтарного |
| запах | Aromatic, aniline-like. |
| Предел воздействия | TLV-TWA 2 ppm (～9 mg/m3) (ACGIH),5 ppm (～22 mg/m3) (MSHA, OSHA, andNIOSH); IDLH level 100 ppm (NIOSH);carcinogenicity: Suspected Human Carcino gen (ACGIH), Human Limited Evidence(IARC). |
| Merck | 14,9536 |
| BRN | 741981 |
| рКа | 4.44 (при 25 ℃) |
| PH | 7.4 (H2O, 20 ℃) Водный раствор |
| Условия хранения | 2-8 ° C |
| чувствительный | Чувствительность к воздуху и свету |
| Предел взрываемости | 1.5-7.5% (V), |
| Показатель преломления | n20 / D 1.572 (освещен). |
| Физические и химические свойства | Light yellow flammable liquid that turns red-brown when exposed to air and sunlight. |
| Используйте | For dyes, pesticides, pharmaceuticals and organic synthesis intermediates |
95-53-4 – Риск и безопасность
| Коды рисков | R45 – Может вызывать рак R23/25 – Toxic by inhalation and if swallowed. R36 – Раздражает глаза. R50 – Очень токсично для водных организмов R35 – Вызывает серьезные ожоги R20/22 – Вредно при вдыхании и проглатывании. R10 – Легковоспламеняющийся Р39/23/24/25 – R23/24/25 – Токсично при вдыхании, попадании на кожу и проглатывании. R11 – Легковоспламеняющийся |
| Описание безопасности | S53 – Избегайте воздействия – перед использованием получите специальные инструкции. S45 – В случае несчастного случая или плохого самочувствия немедленно обратитесь к врачу (по возможности покажите этикетку). S61 – Избегать попадания в окружающую среду. См. специальные инструкции/паспорта безопасности. S36/37/39 – Носите подходящую защитную одежду, перчатки и средства защиты глаз/лица. S26 – При попадании в глаза немедленно промыть большим количеством воды и обратиться к врачу. S36/37 – Надевайте подходящую защитную одежду и перчатки. S16 – Хранить вдали от источников возгорания. S7 – Держите контейнер плотно закрытым. |
| Идентификаторы ООН | UN 2920 8 / PG 1 |
| WGK Германия | 3 |
| RTECS | XU2975000 |
| F-КОДЫ МАРКИ FLUKA | 8-10-23 |
| ЗКТВ | Да |
| Код ТН ВЭД | 29214300 |
| Класс опасности | 6.1 |
| Группа упаковки | II |
| Токсичность | LD50 перорально у крыс: 0.94 г / кг (Смит) |
Справочная информация
| Aromatic amine compound | O-phenylamine (o-toluidine) is one of the aromatic amine compounds (aromatic amines are compounds composed of phenyl rings and amine groups). The methyl group is attached to different positions of the benzene ring, and its names are also different. There are isomers in these three positions. There are 3 isomers of toluidine, namely o-methylaniline, m-methylaniline and p-methylaniline. o-toluidine is the in-situ substitution product, and m-toluidine is the shift substitution product. O-toluidine, also known as “o-aminotoluene”, is a colorless to light yellow liquid, which turns red-brown when exposed to air and light, and generates white precipitates when exposed to formaldehyde. Slightly soluble in water, soluble in dilute acid, alcohol, and ether. Relative density: 1.004(20 ℃); Melting point:-16.3 ℃ (β type),-24.4 ℃(α type); Boiling point: 199.7 ℃; Flash point: 85 ℃; Self-ignition point: 482.2 ℃; Steam density: 3.69. The vapor and air can form an explosive mixture, and the maximum allowable concentration in the air is 5ppm. When exposed to open flames, it can burn, and when exposed to high fever, it will emit toxic gases. The toxicity is similar to aniline. It is easy to form methemoglobin when entering the body, and neurological disorders and cyanosis occur. O-toluidine is an important intermediate in the production of dyes and pigments. It can be used to prepare direct red 62, red RL, red G, date red GBC, basic fuchsin, chromophore AS-D, acid red 35, 158, 265, solvent red 124, diazo components and coupling components of azo dyes, and organic pigment yellow 14, 17, and blue 19; pesticide raw materials, production of pesticide fungicide “tricyclazole”, insecticide bemarborate, and chloramidine; herbicide acetochlor; raw materials for rubber vulcanization accelerator; saccharin raw materials; corrosion inhibitor raw materials, etc. In organic synthesis, o-toluidine is also used to synthesize heterocyclic compounds indole and its derivatives. Andy edited and sorted out the above information. |
| метод приготовления | 1. in dilute acid medium, this product is prepared by heating o-nitrotoluene together with iron powder and water. 2, o-nitrotoluene and hydrogen are preheated in an electric induction heater, and o-toluidine can also be prepared by hydrogenation in the presence of a copper catalyst. 3, toluene is aminated with sodium amide under the action of rhodium-carbon catalyst to prepare this product. 4. aniline is alkylated with methanol under the catalysis of ferric nitrate and germanium dioxide to prepare o-toluidine products. |
| опасная ситуация | (1) o-toluidine is toxic, inhaled vapor, or absorbed or ingested through the skin can cause poisoning. Is a known carcinogen. (2) flammable, ignition point 482 ℃, steam can form explosive mixture with air. The allowable concentration in the air is 2ppm (9mg/m3) in the United States. |
| harmful effects and poisoning symptoms | the toxicity of this product is similar to aniline. ingestion, inhalation of vapor or absorption through skin can cause poisoning, generate methemoglobin, and cause neurological disorders and hypoxia, headache, cyanosis, weakness, dizziness, drowsiness, microscopic examination of hematuria and other symptoms; contact with the eyes and skin can cause eye burns and dermatitis. O-toluidine has carcinogenic effects and is a known carcinogen. |
| требования к транспортировке | o-toluidine is an organic drug. Dangerous gauge number: 84182. UN No.: 1708/6270/6.1-02/335, domestic name number: 61750; When transporting, the container must be marked with “drugs. |
| метод определения | determination in air: silica adsorption, n-propanol treatment, gas chromatography analysis. |
| магазин | be packed in glass bottles or metal barrels to prevent mechanical damage. Keep in a cool, dry, well-ventilated place. It is best to use open-air or attached warehouses. Fireworks are strictly prohibited. Keep away from places prone to fire. Keep away from light and sealed. Separated from the oxidant. |
| первая помощь | if this chemical enters the eye, wash it with water or eye washing agent immediately; If it comes into contact with skin, wash it with soap and water immediately; If someone inhales a lot, immediately move away from the scene to fresh air, and if necessary, perform artificial respiration. If swallowed, take a large amount of water, induce vomiting, gastric lavage, and immediately send to the hospital for treatment. Meilan is a special antidote. |
| защитные меры | appropriate work clothes should be worn during operation to prevent skin contact. Wear protective glasses to prevent skin and eyes from coming into contact with them. If the permeable work clothes are wet or contaminated, they should be removed immediately. Safety signal indicators, eye washers and flushing equipment shall be prepared at the operation site. |
| измерение уровня глюкозы в крови | blood glucose measurement methods include o-toluidine condensation method, oxidase method and Folin-Wu method, and o-toluidine condensation method is commonly used. This method has a high specificity for the detection of glucose and is not affected by substances other than glucose, so the real glucose value (true sugar value) is measured. The basic principle is that glucose can be condensed with o-toluidine to synthesize blue-green Schiff’s base in a hot acetic acid solution, and the color depth is proportional to the glucose content. When measuring, add o-toluidine color developer to the tested serum and glucose standard solution, compare its optical density, and calculate the glucose content in the blood serum. The normal value of glucose in fasting serum is 70~100mg/dl. |
| химические свойства | light yellow flammable liquid, turned reddish brown when exposed to air and sun. Slightly soluble in water, soluble in ethanol and ether. |
| использование | used as dyes, pesticides, pharmaceuticals and organic synthesis intermediates used as analytical reagents and dye intermediates, and also used in organic synthesis o-toluidine is the fungicide tricyclazole, metalaxyl, furfurfuran, the insecticide and acaricide chloramidine, borer, the intermediates of the herbicides isobutachlor, dioxalamine, acetochlor, etc., are also the main intermediates of dyes, which can produce date red-based GBC, red-based G, red-based RL, tryptopol As-D, acid red 3B, Basic fuchsin, etc., and can produce reactive dyes. It is used to produce dye products such as date red-based GBC, red-based G, red-based RL, tryptophenol ASD, acid pink 3B, basic fuchsin and basic pink T, as well as pesticide chlordimeform, saccharin, vulcanization accelerator, mineralization agent toluene arsenic acid, etc. |
| способ производства | is obtained by reduction of o-nitrotoluene. The reduction reaction can use iron powder as a reducing agent, or it can be hydrogenated at 260-280°C in the presence of a copper catalyst to produce o-toluidine. The content of o-toluidine in industrial products (total amino content) is above 99%, and the hydrogenation reduction method consumes 1300kg of o-nitrotoluene and 940 m3 of hydrogen per ton of product. The preparation method is prepared by catalytic hydrogenation and reduction of o-nitrotoluene. Due to the different hydrogenation catalysts, the reaction conditions are different. For example, with copper catalyst, the reaction temperature is 260 ℃, and nickel catalyst can also be used. |
| Каталог | токсичными веществами |
| классификация токсичности | отравление |
| Острая токсичность | Перорально-крыса LD50: 670 мг/кг; Перорально-мышь LD50: 520 мг/кг |
| данные стимуляции | skin-rabbit 10 mg/24 hours severe; eyes-rabbit 0.75 mg/24 hours severe |
| Характеристики взрывоопасности | blastable when mixed with air |
| характеристики опасности воспламеняемости | open flame flammable; strong reaction with nitric acid; combustion emits toxic nitrogen oxide smoke |
| Характеристики хранения и транспортировки | warehouse ventilation and low temperature drying; Separate storage with acids and oxidants |
| огнетушащее средство | mist water, foam, carbon dioxide, sand |
| профессиональный стандарт | TWA 22 мг/м3; STEL 44 мг/м3 |
| индекс цвета | 37077 |
| (МАИР) классификация канцерогенов | 1 (Vol. Sup 7, 77, 99, 100F) 2012 |
| температура самовозгорания | 899 ° F |
| данные о токсичных веществах | The information is: provide (external link) |
| непосредственная опасная для жизни и здоровья концентрация | 50 частей на миллион |
Фабрика и отгрузка
