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Номер CAS 108-44-1
Содержание 99.50%
Упаковка 200 кг/бочка 1000 кг/IBC
Имена и идентификаторы
| Имя | м-толуидин |
| Синонимы | м-толуидин 3-толуидин m-Toluamine m-Tolylamine M-Toluidine 0 Meta Toluidine 3-Aminotoluene 3-метиланилин 3-METHYLALANINE 3-METHYLANILINE АКОС BBS-00003559 Between toluidine 3-метилбензоламин 3-methylanilinium chloride M-TOLUIDINE FOR SYNTHESIS 1 L M-TOLUIDINE FOR SYNTHESIS 100 ML |
| CAS | 108-44-1 |
| EINECS | 203-583-1 |
| InChI | InChI=1/C7H9N.ClH/c1-6-3-2-4-7(8)5-6;/h2-5H,8H2,1H3;1H |
| InChIKey | JJYPMNFTHPTTDI-UHFFFAOYSA-N |
108-44-1 – Физико-химические свойства
| Молекулярная формула | C7H9N |
| Молярная масса | 107.15 |
| Плотность | 0.999 г/м при 25°C (лит.) |
| Температура плавления | -30 ° C |
| Болинг Точка | 203-204 ° С (горит.) |
| Точка возгорания | 186 ° F |
| Растворимость воды | 0.2 г / 100 мл (20 ºC) |
| Растворимость | 0.2 г / 100 мл (20 ° C) |
| Давление пара | 0.3 гПа (20 °C) |
| Внешний вид | Кристаллическое Твердое или Жидкое |
| Цвет | Белый |
| Предел воздействия | TLV-TWA skin 2-ppm (～9 mg/m3) (ACGIH). |
| Merck | 14,9536 |
| BRN | 635944 |
| рКа | 4.73 (при 25 ℃) |
| PH | 7 (H2O, 20 ℃) |
| Условия хранения | Хранить ниже + 30 ° C. |
| Показатель преломления | n20 / D 1.567 (освещен). |
| Физические и химические свойства | Appearance: colorless transparent oily liquid purity: ≥ 98.5% p-toluidine: ≤ 0.7% o-toluidine: ≤ 0.1% moisture: ≤ 0.3% |
| Используйте | As an intermediate for cationic dyes and color film developers |
108-44-1 – Риск и безопасность
| Коды рисков | R45 – Может вызывать рак R23/24/25 – Токсично при вдыхании, попадании на кожу и проглатывании. R33 – Опасность кумулятивных эффектов R50 – Очень токсично для водных организмов |
| Описание безопасности | S53 – Избегайте воздействия – перед использованием получите специальные инструкции. S28 – При попадании на кожу немедленно промыть большим количеством мыльной пены. S36/37 – Надевайте подходящую защитную одежду и перчатки. S45 – В случае несчастного случая или плохого самочувствия немедленно обратитесь к врачу (по возможности покажите этикетку). S61 – Избегать попадания в окружающую среду. См. специальные инструкции/паспорта безопасности. С28А – |
| Идентификаторы ООН | UN 1708 6.1 / PG 2 |
| WGK Германия | 2 |
| RTECS | XU2800000 |
| F-КОДЫ МАРКИ FLUKA | 8-23 |
| ЗКТВ | Да |
| Код ТН ВЭД | 29171990 |
| Опасная нота | Токсичный |
| Класс опасности | 6.1 |
| Группа упаковки | II |
108-44-1 – Справочная информация
| LogP | 1.4 при 25 ℃ |
| Введение | M-Toluidine is a colorless liquid that turns yellow or reddish brown in air or under the action of light. The relative density of 0.989, the melting point of -43.6 deg C, boiling point of 203~204 deg C. Slightly soluble in water, soluble in ethanol and ether. It can be volatilized with water vapor and prepared from M-nitrotoluene by reduction reaction. M-Toluidine is mainly used as a pharmaceutical synthesis intermediate. |
| Процесс подачи заявки | methylaniline is one of the simplest aromatic amines and is also a widely used intermediate in organic synthesis, pharmaceutical and Other Organic synthesis intermediates. At present, the domestic production mainly uses nitrotoluene as raw material, ethanol or methanol as solvent, and Ni as catalyst to prepare methyl aniline by hydrogenation reaction. |
| подготовка | add weighed M-nitrotoluene and nano-catalyst to the autoclave, replace the reactor with nitrogen for 3 times (replacement pressure 0.3MPa), start the stirring; Open the hydrogen cylinder pressure reducing valve and pressure regulating valve, control the hydrogen pressure, and fill the high-pressure reactor with an appropriate amount of hydrogen, and heat up to the temperature in the kettle to the set temperature; Continue to stir and supply hydrogen to the kettle, and remove the reaction heat from the reactor to the cooling water to maintain the stability of the reaction temperature; Until the reactor pressure starts to rise, stop feeding hydrogen and cooling water, continue stirring and heating to maintain the reaction temperature for 0.5h; Stop stirring, separate the catalyst and reaction solution, and remove 30% (mass) of the reaction solution under appropriate conditions, weighing, 3-methylaniline was obtained and the main content was analyzed. It is feasible to prepare 3-methylaniline by using methyl aniline as solvent and catalytic hydrogenation of nitrotoluene with nano catalyst. The catalyst and solvent can be recycled, and the process is safe, environment-friendly, low cost and low energy consumption. The optimal process indexes were as follows: the ratio of nitrotoluene to methylaniline was 4 ∶ 10 (mass ratio), the amount of nano catalyst was 10% of the amount of nitrotoluene, and the reaction temperature was 100~120 ℃, h2 pressure 1.20~1.40 MPa, stirring rate 1500r/min. Under these conditions, the conversion of nitrotoluene was over 88.5%, and the selectivity to methylaniline was 100%. |
| метод синтеза | The hydrogenation reaction of M-nitrotoluene to produce m-toluidine was catalyzed by nickel as a catalyst in an industrial methanol solvent. Through single factor and orthogonal experiments, taking 80g m-nitrotoluene as the calculation standard, under the fixed condition of industrial methanol solvent of 200mL, the optimum reaction conditions were obtained: The catalyst was 2.0g, the reaction time was 6h, the reaction temperature was 90 ℃, and the reaction pressure was 1.6MPa. Under these conditions, the content of M-toluidine was 99.79%, the content of light component was 0.11%, and the content of recombinant component was 0.10%. |
| цель | This product is an intermediate of active yellow X-R and cationic Violet 2RL. use as analytical reagent, also for the synthesis of organic and dyes use as intermediate for cationic dyes, color film developers assay osmium, palladium, platinum, ruthenium and nitrite. |
| способ производства | is prepared by reducing M-nitrotoluene with iron powder. |
| Каталог | токсичными веществами |
| степень токсичности | высокая токсичность |
| Острая токсичность | Перорально-крыса LD50: 450 мг/кг; Перорально-мышь LD50: 740 мг/кг |
| данные стимуляции | Skin-rabbits 500 mg/24 h mild; eye-rabbit 20 mg/24 h moderate |
| характеристики опасности воспламеняемости | flammable in case of open flame; Toxic nitrogen oxide fumes from combustion; reaction with oxidant |
| Характеристики хранения и транспортировки | The warehouse is ventilated and dried at low temperature, separate storage of food additives |
| огнегасящий агент | carbon dioxide, foam, sand, dry powder. |
| Профессиональный стандарт | СВВ 9 мг/м3 |
| температура самовозгорания | > 500 ° С |
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